123853-39-4

Basic information

• Product Name: 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid
• Synonyms: 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid;1,4-Dihydro-2,6-diMethyl-4-(2',3'-dichlorophenyl)-5-carboxy Meth;4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid monomethyl ester;3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-diMethyl-, 3-Methyl ester;Desethyl Felodipine;4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl ester;Monomethyl Felodipine;-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid
• CAS NO: 123853-39-4
• Molecular Formula: C₁₆H₁₅Cl₂NO₄
• Molecular Weight: 357.20854
• Mol File: 123853-39-4.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 483.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.375±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 1.65±0.70(Predicted)
• CAS DataBase Reference: 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid(123853-39-4)
• EPA Substance Registry System: 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid(123853-39-4)

Safety Data

• Hazardous Substances Data: 123853-39-4(Hazardous Substances Data)

Usage

Uses

Desethyl Felodipine is an impurity in the synthesis of Felodipine (F232375), a dihydropyridine calcium channel blocker.

Upstream product

• 110962-94-2 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate methyl ester-(2-cyanoethyl)ester 
• 105-45-3 acetoacetic acid methyl ester 
• 6334-18-5 2,3-dichlorobenzylaldehyde 
• 74073-22-6 (E/Z)-methyl 2-(2,3-dichlorobenzylidene)acetoacetate 
• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 
• 14205-39-1 methyl 3-aminocrotonate 
• 74073-26-0 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate-(tert-butyl) methylester 
• 91189-59-2 4-(-2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl ester 
• 138279-28-4 (+)-methyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 
• 141600-77-3 4-(2,3-Dichloro-phenyl)-1-methoxymethyl-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 

Downstream Products

• 166432-28-6 clevidipine 
• 127634-16-6 (S)-4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-((R)-carboxy-phenyl-methyl) ester 5-methyl ester 
• 127634-15-5 (R)-4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-((R)-carboxy-phenyl-methyl) ester 5-methyl ester 
• 133510-16-4 5-Chlorocarbonyl-4-(2,3-dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylic acid methyl ester 

Relevant articles and documents

Preparation method of dihydropyridine compound (by machine translation)

Compared with the prior art, the method disclosed by the invention is suitable, for industrial production, II is, suitable for industrial production, is suitable for, industrial production, and is suitable for I. industrial production. (by machine transla

Butyric acid clevidipine preparation method

The invention discloses a preparation method of clevidipine butyrate, comprising the following steps: (1) carrying out one-pot reaction by putting 2,3-dichlorobenzaldehyde, methyl acetoacetate and 3-amino crotonic acid ethyl cyanide in a solvent under the action of a catalyst; (2) carrying out recrystallization to obtain a pure product (+/-)-3-(2-cyanoethyl)-5-methyl-4-(2',3'-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid; (3) carrying out a reaction between the pure product and alkali; (4) adding water and hydrochloric acid, and collecting an intermediate from reaction products; and (5) carrying out a reaction between the intermediate and n-chloromethyl butyrate in the presence of an alkaline substance and an iodide catalyst, and finally collecting the target product clevidipine butyrate from reaction products. The preparation method provided by the invention has advantages of high yield, stable product quality and low cost, is simple to operate, and is suitable for industrial product of clevidipine butyrate.

Butyric acid clevidipine synthetic method

The invention discloses a synthetic method of cleviprex. The method comprises the following steps: reacting a compound 1 with a compound 2 in the presence of tetrahydrofuran and triethylamine to generate a compound 3, dissolving the compound 3, a compound