123715-02-6 Usage
Description
2,6-Dimethyl-L-tyrosine (Dmt) is an amino acid derivative that possesses unique structural features, including two methyl groups at the 2nd and 6th positions of the tyrosine molecule. These modifications contribute to its enhanced receptor affinity and functional bioactivity, making it a valuable compound in the field of pharmaceuticals and biochemistry.
Uses
Used in Pharmaceutical Industry:
2,6-Dimethyl-L-tyrosine is used as a building block for the development of opioid peptides, which are crucial in the treatment of pain management. Its incorporation into these peptides enhances their receptor affinity, leading to improved functional bioactivity and increased in vivo analgesic effects. This makes Dmt a valuable component in the design and synthesis of novel pain-relieving drugs.
Used in Pain Management:
2,6-Dimethyl-L-tyrosine is used as an enhancer for opioid peptides in pain management applications. By improving the receptor affinity and bioactivity of these peptides, Dmt contributes to the development of more effective analgesic agents. This can potentially lead to better pain relief and improved quality of life for patients suffering from various types of pain, including chronic and acute conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 123715-02-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,7,1 and 5 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 123715-02:
(8*1)+(7*2)+(6*3)+(5*7)+(4*1)+(3*5)+(2*0)+(1*2)=96
96 % 10 = 6
So 123715-02-6 is a valid CAS Registry Number.
123715-02-6Relevant articles and documents
An Efficient and Highly Asymmetric Synthesis of (S)-2’,6’-Dimethyltyrosine
He, Kailun,Zhu, Fangmeng,Li, Hua,Tang, Jian,Zhang, Xingxian
, p. 510 - 516 (2020)
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Preparation method of 2,6-dimethyl-L-tyrosine
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Paragraph 0056-0066, (2019/01/05)
The invention discloses a preparation method of 2,6-dimethyl-L-tyrosine. The preparation method comprises the steps as follows: halide is added to an organic solvent and subjected to an SN2 nucleophilic addition reaction with L-camphor glycinate under the alkaline condition to produce a chiral compound (III); a compound (IV) is obtained after removal of a chiral auxiliary group from the compound (III); the target compound 2,6-dimethyl-L-tyrosine is obtained after removal of a protecting group from the compound (IV). The method has the characteristics that raw materials are cheap and easy to obtain, the reaction route is short, the operation is convenient, the yield and the stereoselectivity are high and the like, and the method has higher industrial application and economic value.
PROCESSES FOR PREPARING PHARMACEUTICALLY RELEVANT PEPTIDES
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Paragraph 0155, (2016/09/26)
The present technology provides methods of generating the peptides, and pharmaceutically acceptable salts of the peptides and intermediates thereof. In some embodiments, the peptide is D-Arg-2′6′-Dmt-Lys-Phe-NH2.