123705-53-3

Basic information

• Product Name: 3-(4,5-diphenyloxazol-2-yl)propanenitrile
• Synonyms: 3-(4,5-diphenyloxazol-2-yl)propanenitrile
• CAS NO: 123705-53-3
• Molecular Weight: 274.322
• Mol File: 123705-53-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(4,5-diphenyloxazol-2-yl)propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4,5-diphenyloxazol-2-yl)propanenitrile(123705-53-3)
• EPA Substance Registry System: 3-(4,5-diphenyloxazol-2-yl)propanenitrile(123705-53-3)

Safety Data

• Hazardous Substances Data: 123705-53-3(Hazardous Substances Data)

Upstream product

• 451-40-1 phenyl benzyl ketone 
• 110-61-2 butanedinitrile 
• 501-65-5 diphenyl acetylene 

Downstream Products

• 21256-18-8 3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid 

Relevant articles and documents

One-pot preparation of 2,5-disubstituted and 2,4,5-trisubstituted oxazoles from aromatic ketones with molecular iodine, oxone, and trifluoromethanesulfonic acid in nitriles

Alkyl aryl ketones were successfully converted into the corresponding 2,5-disubstituted and 2,4,5-trisubstituted oxazoles in good to moderate yields in a one-pot manner, utilizing iodine, Oxone, and trifluoromethanesulfonic acid in nitriles under transition-metal-free conditions. The present method could be used for the preparation of Oxaprozin from benzyl phenyl ketone and succinonitrile. A possible reaction mechanism was proposed in which the key intermediates were α-iodoalkyl aryl ketones and α-iodosylalkyl aryl ketones.

Synthesis of Oxazoles by the Reaction of Ketones with Iron(III) Solvates of Nitriles

Oxazoles having functionalized carbon substituents at the C-2 position were synthesized in one step by the oxidation of ketones with iron(III) solvates of nitriles, i.e., Fe(RCN)6(ClO4)3(solvate A) or Fe(RCN)6)FeCl4)3(solvate B), in the corresponding nitriles.Keywords oxazole; ketone; oxidation; nitrile; iron(III) nitrile solvate