123702-97-6

Basic information

• Product Name: Moracin O
• Synonyms: Moracin O;5-[(6R)-5,6-Dihydro-6-(1-hydroxy-1-methylethyl)benzo[1,2-b:5,4-b']difuran-2-yl]-1,3-benzenediol;(R)-(-)-Moracin O
• CAS NO: 123702-97-6
• Molecular Formula: C₁₉H₁₈O₅
• Molecular Weight: 326.34322
• Mol File: 123702-97-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Moracin O(CAS DataBase Reference)
• NIST Chemistry Reference: Moracin O(123702-97-6)
• EPA Substance Registry System: Moracin O(123702-97-6)

Safety Data

• Hazardous Substances Data: 123702-97-6(Hazardous Substances Data)

Usage

General Description

Moracin O is a natural organic compound found in the extracts of Morus alba (white mulberry) leaves. It belongs to the chemical class of flavonoids, which are known for their antioxidant and anti-inflammatory properties. Moracin O has been found to possess various pharmacological activities, including anti-diabetic, neuroprotective, and anti-cancer effects. It also exhibits inhibitory activity against enzymes involved in the degradation of carbohydrates, making it a potential candidate for the treatment of diabetes. Additionally, Moracin O has been investigated for its potential role in protecting nerve cells and reducing inflammation in the brain, suggesting its potential for the treatment of neurodegenerative diseases. Overall, the compound shows promise for various therapeutic applications and continues to be of interest for further research and development.

Upstream product

• 1155310-20-5 (R)-2-{6-[3,5-bis-(tert-butyl-dimethylsilanyloxy)-phenyl]-2,3,5,6-tetrahydrobenzo[1,2-b;5,4-b']difuran-2-yl}-propa-2-ol 

Related news

HIF-1α inhibitors: Synthesis and biological evaluation of novel Moracin O (cas 123702-97-6) and P analogues08/08/2019

The natural products moracins O and P exhibited potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia. Systematic variations of the structures of benzofuran type moracins were made and structure-a...detailed

Relevant articles and documents

Bioactive benzofuran derivatives from cortex mori radicis, and their neuroprotective and analgesic activities mediated by mGluR1

Four new benzofuran-type stilbene glycosides and 14 known compounds including 8 benzofuran-type stilbenes and 6 flavonoids were isolated from the traditional Chinese medicine, Cortex Mori Radicis. The new compounds were identified as (9R)-moracin P 3′-O-α-L-arabinopyranoside (1), (9R)-moracin P 9-O-β-D-glucopyranoside (2), (9R)-moracin P 3′-O-β-D-glucopyranoside (3), and (9R)-moracin O 10-O-β-D-glucopyranoside (4) based on the spectroscopic interpretation and chemical analysis. Three benzofuran-type stilbenes, moracin O (5), R (7), and P (8) showed significant neuroprotective activity against glutamate-induced cell death in SK-N-SH cells. In addition, moracin O (5) and P (8) also demonstrated a remarkable inhibition of the acetic acid-induced pain. The molecular docking with metabotropic glutamate receptor 1 (mGluR1) results indicated that these neuroprotective benzofuran-type stilbenes might be the active analgesic components of the genus Morus, and acted by mediating the mGluR1 pathway.