1235126-46-1

Basic information

• Product Name: Linderaspirone A
• Synonyms: Linderaspirone A;(8R,16R)-rel-2,3,6,11,12,14-Hexamethoxy-8,16-diphenyldispiro[4.3.4.3]hexadeca-2,6,11,14-tetraene-1,4,10,13-tetrone
• CAS NO: 1235126-46-1
• Molecular Formula: C34H32O10
• Molecular Weight: 600.61
• Mol File: 1235126-46-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 826.5±65.0 °C(Predicted)
• Appearance: /
• Density: 1.33±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Linderaspirone A(CAS DataBase Reference)
• NIST Chemistry Reference: Linderaspirone A(1235126-46-1)
• EPA Substance Registry System: Linderaspirone A(1235126-46-1)

Safety Data

• Hazardous Substances Data: 1235126-46-1(Hazardous Substances Data)

Usage

General Description

Linderaspirone A is a chemical compound isolated from the marine-derived fungus Penicillium sp. F70614. It exhibits antifungal activity against the pathogenic yeast Candida albicans. Linderaspirone A also displays moderate cytotoxicity against a panel of human cancer cell lines. Its unique structure features a 5,7-fused bicyclic system with a γ-lactam ring and a tetrahydrofuran ring, making it a promising candidate for further drug development. Overall, Linderaspirone A shows potential as a therapeutic agent for treating fungal infections and cancer.

Upstream product

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Relevant articles and documents

A pair of windmill-shaped enantiomers from lindera aggregata with activity toward improvement of insulin sensitivity

(Figure Presented) (+)-Linderaspirone A and (-)-linderaspirone A, a pair of natural windmill-shaped enantiomers, were isolated from the traditional Chinese medicine plant Lindera aggregate by HPLC using a chiral column, achieving over 98% ee. Their structures and absolute configurations were determined on the basis of extensive analysis of NMR spectra, crystal X-ray diffraction, and calculation of the optical rotations (OR). They have an unprecedented carbon skeleton and showed significant activity against glucosamine-induced insulin resistance.

One-step biomimetic synthesis of (±)-linderaspirone A and (±)-bi-linderone

A one-step biomimetic synthesis of racemic linderspirone and bi-liderone from methyllinderone has been achieved, which probably reflects the biosynthesis of the natural products. There are few naturally occurring substances that appear to be formed by a [