123388-07-8

Basic information

• Product Name: 3,4-dihydro-2-<5-methoxy-2<3-ethyl>amino>propoxy>phenyl>-4-methyl-3-oxo-2H-1,4-benzothiazine
• Synonyms: 3,4-dihydro-2-<5-methoxy-2<3-ethyl>amino>propoxy>phenyl>-4-methyl-3-oxo-2H-1,4-benzothiazine
• CAS NO: 123388-07-8
• Molecular Weight: 536.649
• Mol File: 123388-07-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,4-dihydro-2-<5-methoxy-2<3-ethyl>amino>propoxy>phenyl>-4-methyl-3-oxo-2H-1,4-benzothiazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dihydro-2-<5-methoxy-2<3-ethyl>amino>propoxy>phenyl>-4-methyl-3-oxo-2H-1,4-benzothiazine(123388-07-8)
• EPA Substance Registry System: 3,4-dihydro-2-<5-methoxy-2<3-ethyl>amino>propoxy>phenyl>-4-methyl-3-oxo-2H-1,4-benzothiazine(123388-07-8)

Safety Data

• Hazardous Substances Data: 123388-07-8(Hazardous Substances Data)

Upstream product

• 93848-37-4 3,4-Dihydro-2-(2-hydroxy-5-methoxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine 
• 93848-31-8 2-<2-(3-chloropropoxy)-5-methoxyphenyl>-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzothiazine 
• 116354-42-8 N-methyl-N-<2-<3,4-(methylenedioxy)phenoxy>ethyl>amine 

Downstream Products

• 116476-13-2 2-[2-(3-{[2-(Benzo[1,3]dioxol-5-yloxy)-ethyl]-methyl-amino}-propoxy)-5-methoxy-phenyl]-4-methyl-4H-benzo[1,4]thiazin-3-one 
• 116476-13-2 2-[2-(3-{[2-(Benzo[1,3]dioxol-5-yloxy)-ethyl]-methyl-amino}-propoxy)-5-methoxy-phenyl]-4-methyl-4H-benzo[1,4]thiazin-3-one 

Relevant articles and documents

Synthesis and Ca2+ Antagonistic Activity of 2--5-methoxyphenyl>-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzothiazines

As an extension of the previous investigation (J.Med.Chem. 1988, 31, 919), we synthesized a series of 2-5-methoxyphenyl>-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzothiazines (3) and evaluated their Ca2+ antagonistic activities.Ca2+ antagonistic activity was measured with isolated depolarized guinea pig taenia cecum.On the basis of their potent Ca2+ antagonistic activity, six benzothiazines were selected and further evaluated for their vasocardioselectivity.Among these six compounds, the key compound 15 ethyl>amino>propoxy>phenyl>- 4-methyl-3-oxo-2H-1,4-benzothiazine hydrogen fumarate was recognized as having the lowest cardioselectivity.Following optical resolution, the absolute configuration of the compound's optically active enantiomer was determined by means X-ray crystallography of a synthetic precursor (+)-4a.The Ca2+ antagonistic activity of 15 was found to reside primarily in (+)-15 (which was about 7 times more potent than (-)-15).The in vitro study showed that (+)-15 had a low cardioselectivity compared to verapamil and diltiazem.This result suggests that (+)-15 would exhibit less adverse effects due to cardiac inhibition than diltiazem and verapamil in therapeutic use.