1227-44-7

Basic information

• Product Name: 1,3-Bis(p-methoxyphenyl)urea
• Synonyms: 1,3-Bis(4-methoxyphenyl)urea;1,3-Bis(p-methoxyphenyl)urea;N,N'-Bis(p-methoxyphenyl)urea
• CAS NO: 1227-44-7
• Molecular Formula: C₁₅H₁₆N₂O₃
• Molecular Weight: 272.3
• Mol File: 1227-44-7.mol
• Article Data: 95

Chemical Properties

• Melting Point: 239.0 to 243.0 °C
• Boiling Point: 342.5°C at 760 mmHg
• Flash Point: 160.9°C
• Appearance: /
• Density: 1.249g/cm³
• Vapor Pressure: 7.51E-05mmHg at 25°C
• Refractive Index: 1.639
• CAS DataBase Reference: 1,3-Bis(p-methoxyphenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Bis(p-methoxyphenyl)urea(1227-44-7)
• EPA Substance Registry System: 1,3-Bis(p-methoxyphenyl)urea(1227-44-7)

Safety Data

• Hazardous Substances Data: 1227-44-7(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 21, p. 1546, 1956 DOI: 10.1021/jo01118a626

InChI:InChI=1/C15H16N2O3/c1-19-13-7-3-11(4-8-13)16-15(18)17-12-5-9-14(20-2)10-6-12/h3-10H,1-2H3,(H2,16,17,18)

Upstream product

• 75-44-5 phosgene 
• 104-94-9 4-methoxy-aniline 
• 553-17-3 bis(2-methoxy-phenyl)carbonate 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 201230-82-2 carbon monoxide 
• 38435-51-7 N-hydroxy-4-methoxy-benzenecarboximidoyl chloride 
• 5416-93-3 4-Methoxyphenyl isocyanate 
• 2357-47-3 4-Fluoro-3-trifluoromethylaniline 
• 55-81-2 4-Methoxyphenethylamine 
• 2393-23-9 4-methoxy-benzylamine 
• 3300-51-4 p-Trifluoromethylbenzylamine 
• 141-97-9 ethyl acetoacetate 
• 100-17-4 para-methoxynitrobenzene 
• 71-43-2 benzene 

Downstream Products

• 29242-84-0 2-chloro-4-methoxyaniline 
• 74-87-3 methylene chloride 
• 123-30-8 4-amino-phenol 
• 15719-64-9 methylammonium carbonate 
• 251468-91-4 1,3 bis(4-methoxyphenyl)barbituric acid 
• 104-94-9 4-methoxy-aniline 
• 56619-94-4 4-methoxy-N-pivaloylaniline 
• 50906-31-5 N-(2-chlorophenyl)-N’-(4-methoxyphenyl)urea 
• 56106-02-6 1-(4-methylphenyl)-3-(4-methoxyphenyl)urea 
• 3746-53-0 N-(4-metoxyphenyl)-N'-phenylurea 
• 67-56-1 methanol 
• 91247-72-2 1-propyl (4-methoxyphenyl)carbamate 
• 10076-13-8 N,N'-bis(4-methoxyphenyl)carbodiimide 
• 1152-75-6 N,N'-bis(4-methoxyphenyl)iminoformamide 

Relevant articles and documents

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Super fast cobalt carbonyl-mediated synthesis of ureas

Fast cobalt carbonyl-mediated generation of ureas from primary amines was performed using high-density microwave irradiation. This enhanced method permitted the preparation of symmetrical ureas in good yields and unsymmetrical ureas in moderate yields. Th

Exploratory studies towards various anion recognition chemistry by two different sized cleft shaped organic ligands

Indole and urea based two organic receptors have been synthesized by an easy synthetic process. These two receptors have strong sensitivity and selectivity for several bio-relevant anions. Receptor 1 and 2 were synthesized from indole-2-carboxylic acid an

Anion-Coordination-Assisted Assembly of Supramolecular Charge-Transfer Complexes Based on Tris(urea) Ligands

Charge-transfer (CT) complexes, formed by noncovalent bonding between electron-rich (donor, D) and electron-deficient (acceptor, A) molecules (or moieties) have attracted considerable attention due to their fascinating structures and potential application

A high yielding, one-pot synthesis of substituted ureas from the corresponding amines using Mitsunobu's reagent

A Mitsunobu-based protocol has been developed for the synthesis of symmetrically and unsymmetrically substituted ureas from a variety of primary and secondary amines using gaseous carbon dioxide, in good to excellent yields. This protocol is mild and efficient compared to other reported methods.

Amide-assisted rearrangement of hydroxyarylformimidoyl chloride to diarylurea

A novel amide-assisted rearrangement reaction of hydroxybenzimidoyl chloride has been established for the efficient synthesis of 1,3-diphenylurea derivatives. A variety of electronically and sterically different 1,3-diphenylurea derivatives can be obtained in good to excellent yields, and a proposed reaction mechanism is also presented.

Oxovanadium(v)-catalyzed amination of carbon dioxide under ambient pressure for the synthesis of ureas

Carbon dioxide is regarded as a reliable C1 building block in organic synthesis because of the nontoxic, abundant, and economical characteristics of carbon dioxide. In this manuscript, a commercially available oxovanadium(v) compound was demonstrated to serve as an efficient catalyst for the catalytic amination of carbon dioxide under ambient pressure in the synthesis of ureas. The catalytic transformation of chiral amines into the corresponding chiral ureas without loss of chirality was also performed. Furthermore, a gram-scale catalytic urea synthesis under ambient pressure was successfully achieved to validate the scalability of this catalytic activation of carbon dioxide. This journal is