1224680-14-1

Basic information

• Product Name: (S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid
• Synonyms: (S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid
• CAS NO: 1224680-14-1
• Molecular Weight: 376.528
• Mol File: 1224680-14-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid(1224680-14-1)
• EPA Substance Registry System: (S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid(1224680-14-1)

Safety Data

• Hazardous Substances Data: 1224680-14-1(Hazardous Substances Data)

Upstream product

• 1224680-11-8 benzyl 6-ethyl-4-(3-hydroxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1224680-12-9 C₂₆H₃₄N₂O₄Si 
• 1224680-13-0 C₁₉H₂₈N₂O₄Si 
• 1224680-15-2 C₁₉H₂₂N₂O*C₁₉H₂₈N₂O₄Si 
• 4949-45-5 benzyl 2-methylacetoacetate 

Downstream Products

• 1365386-49-7 cyclohexylmethyl 6-ethyl-4-(3-hydroxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1224735-53-8 (S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-N-(2-cyclohexyl-2-hydroxyethyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxamide 

Relevant articles and documents

Discovery of 3,4-dihydropyrimidin-2(1H)-ones with inhibitory activity against HIV-1 replication

3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) were selected and derivatized through a HIV-1 replication assay based on GFP reporter cells. Compounds 14, 25, 31, and 36 exhibited significant inhibition of HIV-1 replication with a good safety profile. Chiral separation of each enantiomer by fractional crystallization showed that only the S enantiomer retained anti-HIV activity. Compound (S)-40, a novel and potent DHPM analog, could serve as an advanced lead for further development and the determination of the mechanism of action.