122320-73-4 Usage
Description
Rosiglitazone, also known as (±)-5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione, is a thiazolidinedione antidiabetic agent. It is a white to off-white solid with pKa values of 6.8 and 6.1, readily soluble in ethanol and a buffered aqueous solution with a pH of 2.3. Rosiglitazone functions as a potent and selective PPARγ agonist, acting as an insulin sensitizer by binding to the peroxisome proliferator-activated receptor gamma (PPAR-γ). This increases insulin sensitivity in peripheral tissues, primarily lowering blood glucose levels in patients with type 2 diabetes mellitus. It is available as the maleate salt in tablets containing the drug alone (Avandia) or in combination products with metformin (Avandamet) or with glimepiride (Avandaryl). The 2-aminopyridine moiety allows for salt formation, with the marketed formulations containing the 1:1 salt with maleic acid.
Uses
Used in Antidiabetic Applications:
Rosiglitazone is used as an antidiabetic agent for lowering blood glucose levels in patients with type 2 diabetes mellitus. It increases insulin sensitivity in peripheral tissues, making the cells of the body more responsive to the naturally produced insulin.
Used in Insulin Sensitization:
Rosiglitazone is used as an insulin sensitizer, enhancing the body's response to insulin and improving glucose uptake in peripheral tissues.
Used in PPARγ Agonism:
Rosiglitazone is used as a potent and selective PPARγ agonist, targeting the peroxisome proliferator-activated receptor gamma (PPAR-γ) to modulate gene expression and improve insulin sensitivity.
Used in Pharmaceutical Formulations:
Rosiglitazone is used in the development of pharmaceutical formulations, such as tablets and combination products, to treat type 2 diabetes mellitus. It is available under the brand name Avandia (GlaxoSmithKline) and in combination with other drugs like metformin (Avandamet) and glimepiride (Avandaryl).
References
[1] http://www.nejm.org/doi/full/10.1056/NEJMoa072761#t=article
[2] http://circ.ahajournals.org/content/128/8/785
[3] https://www.drugs.com/cdi/rosiglitazone.html
Indications
Rosiglitazone is approved for use as monotherapy
and in conjunction with metformin, though it is sometimes
combined with a sulfonylurea or insulin. It is usually
taken once or twice a day with or without food.
Rosiglitazone may cause a modest increase in lowdensity
lipoprotein and triglyceride concentrations, but
it is unclear whether this effect has any clinical significance
or persists in the long term.
Biological Activity
rosiglitazone is a potent agonist of peroxisome proliferator-activated receptor γ (pparγ), a subfamily of the nuclear-receptor superfamily which is predominately expressed in adipose tissue and regulates gene expression responding to ligand binding. belonging to the thiazolidinedione (tzd) class, rosiglitazone, like other tzd members, binds to pparγ dna as heterodimers and activate transcription of various metabolic regulators involved in the differentiation of stem cells into adipocytes and increased expression of genes regulating the metabolism of glucose and lipid. rosiglitazone is used to treat patients with type ii diabetes mellitus for its strong ability to improve insulin sensitization through its effects either on fatty acid uptake and storage in adipose tissue or on adiokines.peter j. cox, david a. ryan, frank j. hollis, ann-marie harris, ann k. miller, marika vousden and hugh cowley. absorption, disposition, and metabolism of rosiglitazone, a potent thiazolidinedione insulin sensitizer, in humans. drug metabolism and disposition 2000; 28 (7): 772-780adie vilioen and alan sinclair. safety and efficacy of rosiglitazone in the elderly diabetic patient. vascular health and risk management 2009: 5 389-395
Biochem/physiol Actions
Rosiglitazone is a potent agonist for PPARγ with an EC50 of 43 nM for the human receptor. It is antidiabetic, working as an insulin sensitizer by binding to the PPARγ receptors in fat cells and making the cells more responsive to insulin.
Clinical Use
Although rosiglitazone is extensively biotransformed—playing the major role in both transformations, and some involvementof CYP2C9.21,47 The sulfate conjugate M10 is thepredominant circulating metabolite by 4-hour postdose. Theextraordinarily high plasma protein binding of this metabolite(and the N-demethylated sulfate conjugate M4) in humans accountsfor the lengthy residence time of the radioactivity in thebody, despite the relatively short pharmacokinetic half-life(4–4.5 hours) of rosiglitazone itself.
Check Digit Verification of cas no
The CAS Registry Mumber 122320-73-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,3,2 and 0 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 122320-73:
(8*1)+(7*2)+(6*2)+(5*3)+(4*2)+(3*0)+(2*7)+(1*3)=74
74 % 10 = 4
So 122320-73-4 is a valid CAS Registry Number.
InChI:InChI=1/C18H19N3O3S.ClH/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15;/h2-9,15H,10-12H2,1H3,(H,20,22,23);1H
122320-73-4Relevant articles and documents
Synthetic optimization of rosiglitazone and related intermediates for industrial purposes
Meng, Ge,Zheng, Meilin,Dong, Mengshu,Gao, Yang,Zheng, Aqun,Li, Zhenyu,Hu, Ruizhi
, p. 2023 - 2033 (2016)
As an important newly Food and Drug Administration (FDA)-approved drug for treating diabetes, rosiglitazone (1) has received much attention from researchers in many areas. To search for an economical and convenient synthesis method for 1, we explored the reaction conditions and workup of a scalable five-step synthetic route by an orthogonal method to determine the best condition for each reaction step. The starting materials are commercially available, including 2-chloropyridine (2), N-methylethanolamine (3), 4-fluorobenzaldehyde (4a) or 4-hydroxybenzaldehyde (4b), and 1,3-thiazolidine-2,4-dione (5). The five sequential reaction steps are cyclization, alkylation, etherification, condensation, and reduction, having optimal yield of 90, 99, 59, 75, and 91 %, respectively. The best overall yield to synthesize rosiglitazone based on compound 2 was 40 %, being suitable for industrial purposes, using water as a green solvent and avoiding column chromatography during the last three reaction steps.
Preparation method of rosiglitazone
-
, (2020/12/29)
The invention provides a preparation method of rosiglitazone. The preparation method is characterized by comprising the following steps: reacting 2-chloropyridine with 2-methylaminoethanol under the catalysis of sodium triphenylmethyl to generate 2-[N-methyl-N-(2-pyridine) amino] ethanol; then carrying out Williamson synthesis reaction on the 2-[N-methyl-N-(2-pyridine) amino] ethanol and 4-fluorobenzaldehyde under the catalysis of bis (trimethylsilyl) amino potassium to obtain 4-[2-[N-methyl-N-(2-pyridine) amino] ethoxy] benzaldehyde; then carrying out condensation reaction with thiazoline-2,4-diketone to obtain 5-{4-[2-[N-methyl-N-(2-pyridine) amino] ethoxy] benzylidene} thiazoline-2, 4-diketone; and carrying out reduction reaction under the catalysis of an organic manganese reagent to obtain the rosiglitazone. The preparation method is simple, mild in condition, high in reaction yield and suitable for industrial production.
Robust Acenaphthoimidazolylidene Palladacycles: Highly Efficient Catalysts for the Amination of N-Heteroaryl Chlorides
Deng, Qinyue,Zhang, Yang,Zhu, Haibo,Tu, Tao
supporting information, p. 2364 - 2368 (2017/09/06)
A series of robust N-heterocyclic carbene palladacycles have been successfully developed. These showed high catalytic activity and selectivity toward the challenging amination of N-heteroaryl chlorides. Different primary and secondary amines were fully compatible with this catalytic system. Remarkably, no double amination products could be detected when primary amines were utilized in our catalytic transformation. Furthermore, the protocol has been successfully extended to synthesize rosiglitazone, a clinical drug for diabetes mellitus, highlighting its potential pharmaceutical feasibility.