1222778-67-7 Usage
Description
(3S,7R,8aS)-3-isobutyloctahydropyrrolo[1,2-a]pyrazine-7-ol, commonly known as ibotenic acid, is a naturally occurring chemical compound found in certain mushrooms, such as Amanita muscaria. It functions as a potent agonist at the glutamate receptor, particularly targeting the N-methyl-D-aspartate (NMDA) receptor. Ibotenic acid is recognized for its neurotoxic properties, which can result in excitotoxicity and neuronal cell death at high concentrations. Its potential therapeutic applications are being explored for the treatment of various neurological disorders, including Alzheimer's disease and epilepsy. Furthermore, ibotenic acid plays a significant role in research aimed at understanding the glutamate system's function within the brain.
Uses
Used in Pharmaceutical Industry:
Ibotenic acid is utilized as a therapeutic agent for the potential treatment of neurological disorders such as Alzheimer's disease and epilepsy. Its action as an NMDA receptor agonist allows it to modulate glutamate signaling, which is implicated in these conditions.
Used in Neuroscientific Research:
In the field of neuroscientific research, ibotenic acid serves as a valuable tool for studying the function and role of the glutamate system in the brain. Its ability to activate NMDA receptors helps researchers investigate the mechanisms underlying neuronal communication and the impact of excitotoxicity on neuronal cell death.
Check Digit Verification of cas no
The CAS Registry Mumber 1222778-67-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,2,7,7 and 8 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1222778-67:
(9*1)+(8*2)+(7*2)+(6*2)+(5*7)+(4*7)+(3*8)+(2*6)+(1*7)=157
157 % 10 = 7
So 1222778-67-7 is a valid CAS Registry Number.
1222778-67-7Relevant articles and documents
Enantiomerically pure piperazines via NaBH4/I2reduction of cyclic amides
Harish, Vagala,Periasamy, Mariappan
, p. 175 - 180 (2017)
Enantiomerically pure (3S,7R,8aS)-3-phenyloctahydropyrrolo[1,2-a]pyrazine-7-ol, (3S,7R,8aS)-3-methyl octahydropyrrolo[1,2-a]pyrazine-7-ol, (3S,7R,8aS)-3-isopropyloctahydropyrrolo[1,2-a]pyrazine-7-ol and (3S,7R,8aS)-3-isobutyloctahydropyrrolo[1,2-a]pyrazine-7-ol 16d were synthesized via preparation of the corresponding cyclic amides from enantiomerically pure L-proline and hydroxyproline derivatives followed by reduction using sodium borohydride-iodine.
