1221485-83-1 Usage
Description
Skepinone-L is an ATP-competitive inhibitor of p38 MAPK isoforms p38α and p38β, with high selectivity and potency, characterized by its ability to impair platelet activation and thrombus formation.
Uses
Used in Pharmaceutical Industry:
Skepinone-L is used as a potent and highly selective inhibitor of p38 MAP kinase for its ability to impair platelet activation and thrombus formation, making it a valuable tool in the development of therapeutics targeting inflammatory and cardiovascular diseases.
Used in Research Applications:
Skepinone-L is used as a research tool for studying the role of p38 MAP kinase in various cellular processes, including the inhibition of heat shock protein 27 (HSP27) phosphorylation and the prevention of cytosolic phospholipase A2 phosphorylation in platelets, which helps in understanding the mechanisms of platelet secretion and aggregation.
references
[1]. koeberle, s c et al., skepinone-l is a selective p38 mitogen-activated protein kinase inhibitor. nature chemical biology, 2012, 8(2), 141-143.
Check Digit Verification of cas no
The CAS Registry Mumber 1221485-83-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,1,4,8 and 5 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1221485-83:
(9*1)+(8*2)+(7*2)+(6*1)+(5*4)+(4*8)+(3*5)+(2*8)+(1*3)=131
131 % 10 = 1
So 1221485-83-1 is a valid CAS Registry Number.
1221485-83-1Relevant articles and documents
Design, synthesis, and structure–activity relationship study of potent mapk11 inhibitors
Gong, Mengdie,Li, Honglin,Li, Lu,Li, Shiliang,Sun, Hongxia,Tu, Mingyan,Zhao, Zhenjiang,Zhu, Lili
, (2022/01/04)
Huntington’s disease (HD) is a rare single-gene neurodegenerative disease, which can only be treated symptomatically. Currently, there are no approved drugs for HD on the market. Studies have found that MAPK11 can serve as a potential therapeutic target f