1218777-13-9 Usage
Description
CAY10505 is a phosphoinositide 3-kinase gamma (PI3Kγ) specific inhibitor, which is a small molecule compound designed to target and inhibit the activity of the PI3Kγ enzyme. This enzyme plays a crucial role in various cellular processes, including cell growth, survival, and metabolism. By inhibiting PI3Kγ, CAY10505 has the potential to modulate these processes and impact various diseases and conditions.
Uses
Used in Pharmaceutical Industry:
CAY10505 is used as a PI3Kγ specific inhibitor for the treatment of hypertension-associated vascular endothelial dysfunction. By targeting the PI3Kγ enzyme, it can help improve the function of blood vessels and reduce the negative effects of hypertension on the vascular system.
Additionally, due to its inhibitory effect on the PI3Kγ enzyme, CAY10505 may have potential applications in other therapeutic areas, such as cancer treatment, where the PI3Kγ pathway is often dysregulated and contributes to tumor growth and progression. Further research and development would be required to explore these potential applications fully.
Biological Activity
cay10505 is a potent and selective pi3kγ inhibitor (ic50= 30 nm)pi3k (phosphatidylinositol-4,5-bisphosphate 3-kinase) is a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. it plays a key role in pi3k/akt/mtor pathway.in neurons treated with 3.5 μm ba, 200 nm cay10505 partially reduced the baicalein-induced akt phosphorylation. [1]in hypertensive rats, cay10505 at 0.6 mg.kg-1 p.o. exhibited the following effects 1) effectively reduced mabp; 2) significantly ameliorated vascular endothelium dysfunction in hypertensive rats in combination of doca; 3) prominently increased serum nitrite and/or nitrate concentrations.4) prevented hypertension-induced attenuation of ach-induced endothelium-dependent relaxation.[2]
references
[1] tyagi s, sharma s, budhiraja rd. effect of phosphatidylinositol 3-kinase-γ inhibitor cay10505 in hypertension, and its associated vascular endothelium dysfunction in rats. can j physiol pharmacol. 2012 jul;90(7):881-5.[2] sun yy, lin sh, lin hc et al. cell type-specific dependency on the pi3k/akt signaling pathway for the endogenous epo and vegf induction by baicalein in neurons versus astrocytes. plos one. 2013 jul 19;8(7):e69019.
Check Digit Verification of cas no
The CAS Registry Mumber 1218777-13-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,8,7,7 and 7 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1218777-13:
(9*1)+(8*2)+(7*1)+(6*8)+(5*7)+(4*7)+(3*7)+(2*1)+(1*3)=169
169 % 10 = 9
So 1218777-13-9 is a valid CAS Registry Number.
