120964-45-6 Usage
Uses
Used in Pharmaceutical Industry:
3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)is used as a pharmaceutical compound for its potential antiviral and anticancer properties. It has shown potent and selective in vitro and in vivo activities against various viruses and cancer cells, making it a promising candidate for the development of new therapeutic agents.
Used in Antiviral Applications:
In the field of antiviral research, 3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)is used as an inhibitor of S-adenosylhomocysteine hydrolase (SAH), which plays a crucial role in the viral replication process. By targeting this enzyme, the compound can potentially inhibit the growth and spread of viruses, offering a new approach to antiviral therapy.
Used in Anticancer Applications:
3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)is also used in the development of anticancer drugs. It has been tested for its effect on ovarian tumor progression and has shown potential in inhibiting the growth of cancer cells. Additionally, it may be used in combination with other chemotherapeutic agents to enhance their efficacy and overcome drug resistance in cancer treatment.
Used in Drug Delivery Systems:
To improve the bioavailability and therapeutic outcomes of 3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-, various drug delivery systems are being explored. These systems, including organic and metallic nanoparticles, aim to enhance the compound's delivery to target cells, increasing its effectiveness and reducing potential side effects.
Biochem/physiol Actions
3-Deazaneplanocin A (DZNep) is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor. It switches on repressed tumor suppressor genes and induces apoptosis by inhibiting the expression of EZH2.
Check Digit Verification of cas no
The CAS Registry Mumber 120964-45-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,9,6 and 4 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 120964-45:
(8*1)+(7*2)+(6*0)+(5*9)+(4*6)+(3*4)+(2*4)+(1*5)=116
116 % 10 = 6
So 120964-45-6 is a valid CAS Registry Number.
120964-45-6Relevant articles and documents
Synthesis of 3-Deazaneplanocin A, a Powerful Inhibitor of S-Adenosylhomocysteine Hydrolase with Potent and Selective in Vitro and in Vivo Antiviral Activities
Tseng, Christopher K. H.,Marquez, Victor E.,Fuller, Richard W.,Goldstein, Barry M.,Haines, David R.,et al.
, p. 1442 - 1446 (1989)
The neplanocin A analogue 3-deazaneplanocin A (2b) has been synthesized.A direct SN2 displacement on the cyclopentenyl mesylate 3 by the sodium salt of 6-chloro-3-deazapurine afforded the desired regioisomer 4 as the major product.After deprotection, this material was converted to 3-deazaneplanocin A in two steps.X-ray crystallographic analysis confirmed the assigned structure.Consistent with its potent inhibition of S-adenosylhomocysteine hydrolase, 3-deazaneplanocin A displayed excellent antiviral activity in cell culture against vesicular stomatitis, parainfluenza type 3, yellow fever, and vaccinia viruses.Antiviral activitiy was also displayed in vivo against vaccinia virus by using a mouse tailpox assay.The significantly lower cytotoxicity of 3-deazaneplanocin A, relative to its parent compound neplanocin A, may be due to its lack of conversion to 5'-triphosphate and S-adenosylmethionine metabolites.
