120928-09-8 Usage
Description
Fenazaquin is a non-systemic acaricide and insecticide, specifically designed for the control of mites and other related pests in a variety of crops, including fruits, vegetables, and tea. It is known for its effectiveness in managing various mite species, such as Eutetranychus, Panonychus, and Tetranychus spp.
Uses
Used in Agriculture:
Fenazaquin is used as an acaricide and insecticide for the control of mites and related pests in fruits, vegetables, and tea. It is particularly effective against Eutetranychus, Panonychus, and Tetranychus spp., which are common mite species that can cause significant damage to crops.
Used in Pome and Citrus Fruits:
Fenazaquin is used as an acaricide for the control of mites on pome and citrus fruits. By targeting these pests, it helps to protect the quality and yield of these important fruit crops.
Used in Glasshouse-Grown Ornamental Plants:
Fenazaquin is also used as an acaricide in the cultivation of glasshouse-grown ornamental plants. It helps to control mite infestations, ensuring the health and appearance of these plants.
Metabolic pathway
Fenazaquin is a lipophilic compound and hence is immobile in soils and is
not translocated in plants. The main pathways of metabolism involve
cleavage of the bridging group between the quinazoline and phenyl rings,
oxidation of the tert-butyl sustituent and of the heterocyclic portion of the
quinazoline ring and cleavage of that ring. Most of the information is
taken from a pamphlet produced by the manufacturer of the compound in
which full experimental details were not given (DowElanco, 1993).
Degradation
Fenazaquin is hydrolysed under acidic conditions but the rate is slow
under neutral and alkaline conditions. Half-lives were 8,442 and 584 days
(22 °C) at pH values of 5, 7 and 9, respectively. Hydrolysis occurs by
cleavage of the ether linkage to form quinazolin-2-ol (2) and an alcohol
(3) as shown in Scheme 1. The major route of degradation in aquatic
environments is by photolysis, the main products (2 and 3) being formed
by cleavage of the ether lmkage and include the alkene (4) (DowElanco,
1993).
Check Digit Verification of cas no
The CAS Registry Mumber 120928-09-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,9,2 and 8 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 120928-09:
(8*1)+(7*2)+(6*0)+(5*9)+(4*2)+(3*8)+(2*0)+(1*9)=108
108 % 10 = 8
So 120928-09-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H22N2O/c1-20(2,3)16-10-8-15(9-11-16)12-13-23-19-17-6-4-5-7-18(17)21-14-22-19/h4-11,14H,12-13H2,1-3H3
120928-09-8Relevant articles and documents
Preparation method of acaricide of fenazaquin
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Paragraph 0025; 0027; 0028; 0030; 0031; 0033; 0034; 0036, (2020/09/20)
The invention discloses a preparation method of an acaricide of fenazaquin, and belongs to the field of a pesticide raw drug process. The preparation method is implemented through the following stepsthat (1) 4-tertiary butyl phenethyl alcohol is used as r
Insecticidal quinazoline derivatives with (trifluoromethyl)diazirinyl and azido substituents as NADH:ubiquinone oxidoreductase inhibitors and candidate photoaffinity probes
Latli, Bachir,Wood, Edgardo,Casida, John E.
, p. 445 - 450 (2007/10/03)
Two candidate photoaffinity probes are designed from 4-substituted quinazolines known to be potent insecticides/acaricides and NADH:ubiquinone oxidoreductase inhibitors acting at or near the rotenone site. 4-(11- Azidoundecyl-2-amino)quinazoline, based on the undecylamino analog SAN 548A as a prototype, was synthesized in 18% overall yield from ethyl 10- undecenoate by oxidation of the terminal double bond, reductive amination, coupling to 4-chloroquinazoline, and functional group manipulation of the terminal ethyl ester to an alcohol, a mesylate and finally nucleophilic displacement with azide ions. 4-(4-(3-(Trifluoromethyl)-3H-diazirin-3- yl)phenethoxy)quinazoline [the (trifluoromethyl)diazirinyl analog of fenazaquin insecticide/acaricide] was prepared from 4-bromophenethyl alcohol in 31% overall yield by first introducing the trifluoromethylketone moiety followed by its conversion to the (trifluoromethyl)-diazirine and finally coupling to 4-chloroquinazoline as above. Both candidate photoaffinity probes have the inhibitory potency of rotenone (IC50 of 3-4 nM in each case). The azidoundecylamino compound has inadequate photoreactivity whereas that of the (trifluoromethyl)diazirinyl analog is ideal at 350 nm. Radiosynthesis of the latter photoaffinity ligand included introduction of the diazirinyl moiety as the carbene precursor, oxidation of (trifluoromethyl)diazirinylphenethyl alcohol to the corresponding acid with Jones' reagent, and reduction of the phenacetyl chloride intermediate with sodium borotritide to incorporate tritium.