119916-22-2

Basic information

• Product Name: 2-METHYL-3,4,6-TRIFLUORO BENZOIC ACID
• Synonyms: 2,4,5-Trifluoro-6-methylbenzoic acid;2-METHYL-3,4,6-TRIFLUORO BENZOIC ACID;3-Methyl-2,4,5-trifluorobenzoyl chloride;3,4,6-Trifluoro-2-methylbenzoic Acid
• CAS NO: 119916-22-2
• Molecular Formula: C₈H₅F₃O₂
• Molecular Weight: 190.12
• Product Categories: Benzoic acid
• Mol File: 119916-22-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 108-110℃
• Boiling Point: 256.2°Cat760mmHg
• Flash Point: 108.7°C
• Appearance: /
• Density: 1.452g/cm³
• Vapor Pressure: 0.008mmHg at 25°C
• Refractive Index: 1.492
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform; Ethyl Acetate; Methanol
• PKA: 2.59±0.37(Predicted)
• CAS DataBase Reference: 2-METHYL-3,4,6-TRIFLUORO BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-3,4,6-TRIFLUORO BENZOIC ACID(119916-22-2)
• EPA Substance Registry System: 2-METHYL-3,4,6-TRIFLUORO BENZOIC ACID(119916-22-2)

Safety Data

• Hazardous Substances Data: 119916-22-2(Hazardous Substances Data)

Usage

Description

2-METHYL-3,4,6-TRIFLUORO BENZOIC ACID is an organic compound characterized by its trifluoromethyl groups and a methyl group attached to a benzoic acid structure. It is a key intermediate in the synthesis of various pharmaceutical compounds due to its unique chemical properties and reactivity.

Uses

Used in Pharmaceutical Industry:
2-METHYL-3,4,6-TRIFLUORO BENZOIC ACID is used as an intermediate in the synthesis of dl-Grepafloxacin (G783000) for its role in the development of antibacterial compounds. The compound contributes to the creation of effective treatments for various respiratory infections, showcasing its importance in the pharmaceutical sector.

InChI:InChI=1/C8H5F3O2/c1-3-6(8(12)13)4(9)2-5(10)7(3)11/h2H,1H3,(H,12,13)

Upstream product

• 32890-92-9 2,3,4,6-tetrafluorobenzoic acid 
• 57612-65-4 2,3,4,5-tetrafluoro-6-methylbenzoic acid 
• 142603-49-4 2,4,5-trifluoro-6-methylisophthalic acid 
• 132233-72-8 1-bromo-2,4,5-trifluoro-3-(trimethylsilyl)benzene 
• 125290-74-6 2-<2,4,5-trifluoro-6-methyl-3-(trimethylsilyl)phenyl>-4,4-dimethyl-2-oxazoline 
• 125290-73-5 2-<2,4,5-trifluoro-3-(trimethylsilyl)phenyl>-4,4-dimethyl-2-oxazoline 
• 125290-72-4 2-(2,4,5-trifluorophenyl)-4,4-dimethyl-2-oxazoline 
• 132630-85-4 1-bromo-2,4,5-trifluoro-6-methyl-3-(trimethylsilyl)benzene 
• 88419-56-1 2,4,5-trifluorobenzoyl chloride 
• 446-17-3 2,4,5-trifluorobenzoic acid 
• 327-52-6 1-bromo-2,4,5-trifluorobenzene 

Downstream Products

• 119916-38-0 6,7-difluoro-1-(2,4-difluorophenyl)-1,4-dihydro-5-methyl-4-oxo-3-quinolinecarboxylic acid 
• 119915-47-8 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-5-methyl-4-oxo-3-quinolinecarboxylic acid 
• 119915-44-5 ethyl α-(ethoxymethylene)-3,4,6-trifluoro-2-methyl-β-oxobenzenepropanoate 
• 119915-43-4 ethyl (2,4,5-trifluoro-6-methylbenzoyl)acetate 
• 119915-41-2 2-methyl-3,4,6-trifluorobenzoyl chloride 

Relevant articles and documents

QUINOLIN-4-ONE AND 4(1H)-CINNOLINONE COMPOUNDS AND METHODS OF USING SAME

The present disclosure relates to quinolin-4-one and 4(1H)-cinnolinone compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.

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An object of the present invention is to provide a commercially advantageous process for preparing a fluoro benzoic acid. The process according to the present invention comprises either alkylating a fluoro benzoic acid of the formula wherein R1

Synthesis of 5-methyl-4-oxo-quinolinecarboxylic acids

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