119309-02-3

Basic information

• Product Name: Atalantoflavone
• Synonyms: Atalantoflavone;5-Hydroxy-2-(4-hydroxyphenyl)-8,8-dimethyl-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one;Limonianin
• CAS NO: 119309-02-3
• Molecular Formula: C₂₀H₁₆O₅
• Molecular Weight: 336.33804
• Mol File: 119309-02-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 285-293 °C
• Boiling Point: 584.1±50.0 °C(Predicted)
• Appearance: /
• Density: 1.368±0.06 g/cm3(Predicted)
• PKA: 6.48±0.60(Predicted)
• CAS DataBase Reference: Atalantoflavone(CAS DataBase Reference)
• NIST Chemistry Reference: Atalantoflavone(119309-02-3)
• EPA Substance Registry System: Atalantoflavone(119309-02-3)

Safety Data

• Hazardous Substances Data: 119309-02-3(Hazardous Substances Data)

Usage

General Description

Atalantoflavone is a type of natural chemical compound known as a biflavonoid, which is commonly found in various plant species such as Ginkgo biloba and Hypericum perforatum. It has been studied for its potential therapeutic effects, including its anti-inflammatory, anti-cancer, and neuroprotective properties. Atalantoflavone has shown promising results in preclinical studies, with evidence suggesting that it may help to inhibit the growth of cancer cells, reduce inflammation, and protect against neurodegenerative diseases. Additionally, it has been found to have antioxidant and anti-microbial activities, making it a subject of interest for further research into its potential applications in medicine and healthcare. Overall, atalantoflavone is regarded as a biologically active compound that may offer a range of health benefits, although more research is needed to fully elucidate its mechanisms and potential therapeutic applications.

Upstream product

• 107-86-8 3,3-dimethyl acrylaldehyde 
• 520-36-5 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 

Downstream Products

• 119309-04-5 5-methoxy-2-(4-methoxyphenyl)-8,8-dimethyl-4H,8H-benzo[1,2-b:3,4-b’]dipyran-4-one 

Relevant articles and documents

Cytotoxicity and Anti-inflammatory Properties of Apigenin-Derived Isolaxifolin

The rare flavonoid isolaxifolin, a potent insecticide, has been touted as a potential grain-protecting agent. In order to assess any impact of this natural product on human health and to explore its various other biological properties, we have established a semisynthesis from the simpler but structurally related and more abundant natural product apigenin. The five-step reaction sequence has provided, for the first time, sufficient material for an in-depth evaluation of the cytotoxic properties of the title natural product. The impact of isolaxifolin on certain pro-inflammatory cytokines in murine macrophage RAW 264.7 cells has also been examined. Such studies have revealed that isolaxifolin displays no toxic effects toward normal cells while displaying greater cytotoxicities against certain cancer cell lines than its synthetic precursor apigenin. Furthermore, unlike apigenin, isolaxifolin only reduced NO, TNF-α, and IL-6 secretions in LPS-induced RAW 264.7 cells in a rather modest and dose-independent manner.