118758-48-8Relevant articles and documents
Intermediate used for synthesis of (2S, 3R)-3-substituted phenyl pyrrolidine-2-carboxylic acid, and preparation method and applications thereof
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Paragraph 0054; 0066-0067, (2019/12/08)
The invention relates to an intermediate used for synthesis of (2S, 3R)-3-substituted phenyl pyrrolidine-2-carboxylic acid, and a preparation method and applications thereof. The preparation method ismainly used for solving a technical problem that no app
Synthesis of Homochiral 3-Substituted Glutamic Acids and Prolines from Pyroglutamic Acid
Herdeis, Claus,Hubmann, Hans Peter,Lotter, Hermann
, p. 351 - 354 (2007/10/02)
Efficient syntheses of (2S,3S)-methylproline (5a) and (2S,3R)-phenylproline (5b) are described, starting from the readily available pyroglutaminol derivatives 2a and 2b via conjugate 1,4=addition of organocuprates to 1.Catalytic hydrogenation of 3 from th