118078-66-3 Usage
Description
2-Fluoro-4-trifluoromethyl-pyridine is a heterocyclic compound featuring a pyridine ring with a fluorine atom at the 2nd position and a trifluoromethyl group at the 4th position. This molecule is known for its unique electronic properties and reactivity, making it a valuable building block in organic synthesis and a versatile ligand in catalysis.
Uses
Used in Pharmaceutical Industry:
2-Fluoro-4-trifluoromethyl-pyridine is used as a reactant for the preparation of aminopyridines through amination reactions. These aminopyridines are important intermediates in the synthesis of various pharmaceutical compounds, including those with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-Fluoro-4-trifluoromethyl-pyridine serves as a valuable building block for the creation of more complex organic molecules. Its unique structure allows for selective functionalization and the formation of diverse chemical entities.
Used in Catalysis:
2-Fluoro-4-trifluoromethyl-pyridine is used as a catalytic ligand for the regioselective preparation of tetramethylbiphenyls through aerobic oxidative coupling of xylene catalyzed by palladium. This application highlights its utility in transition metal catalysis, where it can modulate the selectivity and efficiency of catalytic processes.
Overall, 2-Fluoro-4-trifluoromethyl-pyridine is a versatile and valuable compound with applications spanning across various industries, including pharmaceuticals, chemical synthesis, and catalysis. Its unique structure and reactivity make it an essential component in the development of new molecules and processes.
Check Digit Verification of cas no
The CAS Registry Mumber 118078-66-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,0,7 and 8 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 118078-66:
(8*1)+(7*1)+(6*8)+(5*0)+(4*7)+(3*8)+(2*6)+(1*6)=133
133 % 10 = 3
So 118078-66-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H3F4N/c7-5-3-4(1-2-11-5)6(8,9)10/h1-3H
118078-66-3Relevant articles and documents
A radical approach to the copper oxidative addition problem: Trifluoromethylation of bromoarenes
Le, Chip,Chen, Tiffany Q.,Liang, Tao,Zhang, Patricia,MacMillan, David W. C.
, p. 1010 - 1014 (2018/06/12)
Transition metal–catalyzed arene functionalization has been widely used for molecular synthesis over the past century. In this arena, copper catalysis has long been considered a privileged platform due to the propensity of high-valent copper to undergo reductive elimination with a wide variety of coupling fragments. However, the sluggish nature of oxidative addition has limited copper’s capacity to broadly facilitate haloarene coupling protocols. Here, we demonstrate that this copper oxidative addition problem can be overcome with an aryl radical–capture mechanism, wherein the aryl radical is generated through a silyl radical halogen abstraction. This strategy was applied to a general trifluoromethylation of aryl bromides through dual copper-photoredox catalysis. Mechanistic studies support the formation of an open-shell aryl species.
