117641-39-1 Usage
Description
(1S,2R,3S,5R)-2-(Benzyloxymethyl)-6-oxabicyclo[3.1.0]hexan-3-ol is a complex organic compound with a unique molecular structure. It is characterized by its bicyclic ring system and the presence of a benzyloxymethyl group, which contributes to its specific properties and potential applications.
Uses
Used in Pharmaceutical Industry:
(1S,2R,3S,5R)-2-(Benzyloxymethyl)-6-oxabicyclo[3.1.0]hexan-3-ol is used as an impurity in the production of Entecavir (E558900), an oral antiviral drug. Entecavir is specifically used in the treatment of hepatitis B infection, acting as a guanine analogue that inhibits all three steps in the viral replication process. The presence of this compound in the production process may affect the drug's efficacy and safety, making it a significant consideration in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 117641-39-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,7,6,4 and 1 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 117641-39:
(8*1)+(7*1)+(6*7)+(5*6)+(4*4)+(3*1)+(2*3)+(1*9)=121
121 % 10 = 1
So 117641-39-1 is a valid CAS Registry Number.
InChI:InChI=1/C13H16O3/c14-11-6-12-13(16-12)10(11)8-15-7-9-4-2-1-3-5-9/h1-5,10-14H,6-8H2/t10-,11+,12-,13+/m1/s1
117641-39-1Relevant articles and documents
A New Route for the Synthesis of Entecavir
Wang, Shan-chun,Zhang, Xi-quan,Gu, Hong-mei,Zhu, Xue-yan,Guo, Ya-jun
, p. 568 - 574 (2017/12/12)
-
Novel 3′-deoxy analogs of the anti-HBV agent entecavir: Synthesis of enantiomers from a single chiral epoxide
Ruediger, Edward,Martel, Alain,Meanwell, Nicholas,Solomon, Carola,Turmel, Brigitte
, p. 739 - 742 (2007/10/03)
A synthesis of novel 3′-deoxy analogs of the anti-HBV agent entecavir (BMS-200475) was devised using regioselective ring opening of suitable cyclopentene epoxides as the key step. This versatile approach afforded access to an enantiomeric pair of carbocyclic nucleosides from a single chiral intermediate.
Enantioselective synthesis of optically active carbocyclic sugars
Gathergood,Knudsen,Jorgensen
, p. 1014 - 1017 (2007/10/03)
-