117408-98-7

Basic information

• Product Name: 2-[(4S)-4-(1,1-diMethylethyl)-4,5-dihydro-2-oxazolyl]-Pyridine
• Synonyms: (S)-4-(tert-butyl)-2-(pyridin-2-yl)-4,5-dihydrooxazole;2-[(4S)-4-tert-Butyl-4,5-dihydro-2-oxazolyl]pyridine;(S)-4-tert-Butyl-2-(2-pyridyl)oxazoline;2-[(4S)-4,5-dihydro-4-(1,1-dimethylethyl)-2-oxazolyl]-Pyridine;2-[(4S)-4-(2-Methyl-2-propanyl)-4,5-dihydro-1,3-oxazol-2-yl]pyridine;2-[(4S)-4-tert-Butyl-4,5-dihydro-2-oxazolyl]pyridine,99%e.e.;2-[(4S)-4-(1,1-diMethylethyl)-4,5-dihydro-2-oxazolyl]-Pyridine;(S)-4-tert-Butyl-2-(2-pyridyl)oxazoline
• CAS NO: 117408-98-7
• Molecular Formula: C₁₂H₁₆N₂O
• Molecular Weight: 204.26824
• Mol File: 117408-98-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 70.0 to 74.0 °C
• Boiling Point: 125-135 °C(Press: 0.1 Torr)
• Appearance: /
• Density: 1.08±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: slightly sol. in dichloromethane
• PKA: 3.79±0.70(Predicted)
• CAS DataBase Reference: 2-[(4S)-4-(1,1-diMethylethyl)-4,5-dihydro-2-oxazolyl]-Pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4S)-4-(1,1-diMethylethyl)-4,5-dihydro-2-oxazolyl]-Pyridine(117408-98-7)
• EPA Substance Registry System: 2-[(4S)-4-(1,1-diMethylethyl)-4,5-dihydro-2-oxazolyl]-Pyridine(117408-98-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 117408-98-7(Hazardous Substances Data)

Usage

General Description

The chemical compound "2-[(4S)-4-(1,1-diMethylethyl)-4,5-dihydro-2-oxazolyl]-Pyridine" is a derivative of pyridine with a structural moiety that includes a 4,5-dihydro-2-oxazolyl group attached to the pyridine ring. 2-[(4S)-4-(1,1-diMethylethyl)-4,5-dihydro-2-oxazolyl]-Pyridine belongs to the class of organic compounds known as phenylpyridines, which are aromatic heteromonocyclic compounds containing a pyridine ring substituted at one or more positions by a phenyl group. The presence of the 4S chirality suggests that this compound has a specific stereochemistry, which can impact its reactivity and biological activity. This chemical may have potential applications in pharmaceuticals, agrochemicals, and other fields due to its unique structural properties. Further studies and research are needed to fully understand its potential uses and properties.

Upstream product

• 112245-13-3 (S)-tert-leucinol 
• 98-98-6 2-Picolinic acid 
• 20859-02-3 L-tert-Leucine 
• 29745-44-6 pyridine-2-carbonyl chloride 
• 19547-38-7 methyl pyridine-2-imidate 
• 100-70-9 2-Cyanopyridine 

Relevant articles and documents

Preparation of (S)-tert-ButylPyOx and palladium-catalyzed asymmetric conjugate addition of arylboronic acids

-

Palladium-catalyzed asymmetric conjugate addition of arylboronic acids to heterocyclic acceptors

Flava Flavanone: Asymmetric conjugate additions to chromones and 4-quinolones are reported utilizing a single catalyst system formed in situ from Pd(OCOCF3)2 and (S)-tBuPyOX. Notably, these reactions are performed in wet solvent under ambient atmosphere, and employ readily available arylboronic acids as the nucleophile, thus providing ready access to these asymmetric heterocycles (see scheme).

Efficient enhancement of copper-pyridineoxazoline catalysts through immobilization and process design

Copper-pyridineoxazoline (Cu-pyox) complexes are poor homogeneous catalysts for asymmetric cyclopropanation reactions. Pyox ligands have been immobilized by polymerization of monomers possessing a vinyl group directly attached to position 6 with styrene a