117399-93-6 Usage
Description
H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH is a peptide sequence consisting of 21 amino acids. It is derived from the endothelin peptide family, specifically Endothelin 3 (ET3), which is a 21-amino acid peptide synthesized as a precursor and later cleaved by proteases to become biologically active. This peptide sequence is localized to the human intestine and colon and has been used in various applications, including culturing neural tube explant culture and pharmacological studies of endothelin receptors.
Uses
Used in Pharmaceutical Applications:
H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH is used as a therapeutic agent for various conditions due to its interaction with endothelin receptors, particularly ETRB. It plays a role in regulating various physiological processes, making it a potential target for drug development.
Used in Research Applications:
H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH is used as a research tool for studying the function and regulation of endothelin receptors, as well as the role of ET3 in various physiological processes. It can be employed in cell culture, molecular biology, and pharmacological studies to better understand the mechanisms underlying its actions.
Used in Drug Delivery Systems:
Similar to gallotannin, H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH can potentially be incorporated into drug delivery systems to enhance its bioavailability, delivery, and therapeutic outcomes. This may involve the use of organic or metallic nanoparticles as carriers for targeted delivery to specific tissues or cells.
Used in Application Industry:
H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH is used as a therapeutic agent in the pharmaceutical industry for the development of drugs targeting endothelin receptors, particularly ETRB, to treat various conditions related to its dysregulation.
H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH is used as a research tool in the biotechnology and life sciences industry for studying the function and regulation of endothelin receptors, as well as the role of ET3 in various physiological processes.
Biochem/physiol Actions
Endothelin 3 (ET3) is a vasoconstrictor that acts in a paracrine and autocrine manner, and in intestinal lamina propria causes the degranulation of mast cells. It results in the release of ions from intestinal epithelial cells. In acute and chronic intestinal inflammation, it is overexpressed. It is also up-regulated in colon carcinoma, where it supports cell proliferation and survival. It might be involved in colon homeostasis, and is essential for the survival and proliferation of goblet cells. In mice, it is essential for the development of pigment cells derived from neural crest (NC). Its expression is de-regulated in metastatic melanoma.
Check Digit Verification of cas no
The CAS Registry Mumber 117399-93-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,7,3,9 and 9 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 117399-93:
(8*1)+(7*1)+(6*7)+(5*3)+(4*9)+(3*9)+(2*9)+(1*3)=156
156 % 10 = 6
So 117399-93-6 is a valid CAS Registry Number.
