116387-40-7

Basic information

• Product Name: METHYL 2-HYDROXY-5-IODONICOTINATE
• Synonyms: METHYL 5-IODO-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE;METHYL 2-HYDROXY-5-IODONICOTINATE;2-Hydroxy-5-iodo-nicotinic acid methyl ester;Methyl 2-hydroxy-5-iodopyridine-3-carboxylate;5-Iodo-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid Methyl ester;2-Hydroxy-5-iodopyridine-3-carboxylic acid methyl ester;Methyl 5-iodo-2-oxo-1,2-dihydropyridine-3-carboxylate;ethyl 2-hydroxy-5-iodonicotinate
• CAS NO: 116387-40-7
• Molecular Formula: C₇H₆INO₃
• Molecular Weight: 279.03
• Mol File: 116387-40-7.mol
• Article Data: 9

Chemical Properties

• Melting Point: 199-201°
• Boiling Point: 362.2°Cat760mmHg
• Flash Point: 172.9°C
• Appearance: /
• Density: 1.98g/cm³
• Vapor Pressure: 1.96E-05mmHg at 25°C
• Refractive Index: 1.634
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: METHYL 2-HYDROXY-5-IODONICOTINATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-HYDROXY-5-IODONICOTINATE(116387-40-7)
• EPA Substance Registry System: METHYL 2-HYDROXY-5-IODONICOTINATE(116387-40-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 116387-40-7(Hazardous Substances Data)

Usage

General Description

Methyl 2-hydroxy-5-iodonicotinate is a chemical compound with the molecular formula C7H7INO3. It is a derivative of nicotinic acid and features a methyl group and a hydroxyl group attached to the pyridine ring, as well as an iodine atom at position 5. METHYL 2-HYDROXY-5-IODONICOTINATE has been used in pharmaceutical research and drug development, particularly for its potential as a precursor to biologically active molecules and as a building block in the synthesis of complex organic compounds. Its unique structure and versatile reactivity make it a valuable compound in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C7H6INO3/c1-12-7(11)5-2-4(8)3-9-6(5)10/h2-3H,1H3,(H,9,10)

Upstream product

• 609-71-2 2-hydroxy-3-carboxypyridine 
• 10128-91-3 methyl 2-hydroxynicotinate 
• 609-71-2 1,2-dihydro-2-oxonicotinic acid 
• 10128-91-3 methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile 

Downstream Products

• 116387-24-7 diethyl N-<4-<<2-(pivaloylamino)-4-hydroxypyrido<2,3-d>pyrimidin-6-yl>ethynyl>benzoyl>-L-glutamate 
• 116387-35-0 2-(pivaloylamino)-4-hydroxy-6-<(carboxyphenyl)ethynyl>pyrido<2,3-d>pyrimidine 
• 116387-33-8 2-amino-4-hydroxy-6-<<4-(tert-butoxycarbonyl)phenyl>ethynyl>pyrido<2,3-d>pyrimidine 
• 116387-38-3 2-amino-4-hydroxy-6-<(4-carbxyphenyl)ethynyl>pyrido<2,3-d>pyrimidine 
• 116387-41-8 methyl 5-<<4-(tert-butoxycarbonyl)phenyl>ethynyl>-2-chloro-3-pyridinecarboxylate 
• 116387-28-1 diethyl N-<4-<<2-(pivaloylamino)-4-hydroxy-5,6,7,8-tetrahydropyrido<2,3-d>pyrimidin-6-yl>ethyl>benzoyl>-L-glutamate 
• 95693-76-8 (6RS)-5,10-dideaza-5,6,7,8-tetrahydrofolic acid 
• 151323-43-2 methyl 5-phenyl-2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxylate 
• 157362-11-3 2-{Butyl-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-5-iodo-nicotinic acid methyl ester 
• 78686-83-6 methyl 2-chloro-5-iodo-3-pyridinecarboxylate 

Relevant articles and documents

AZAQUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF

Compounds of Formula (I) are useful as inhibitors of HIF prolyl hydroxylases where the definitions of the variables are provided herein.

Inhibitors of protein tyrosine phosphatase 1B

Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted bicyclic fused-thiophene compounds can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.

PYRIDONE DERIVATIVE HAVING AFFINITY FOR CANNABINOID 2-TYPE RECEPTOR

It was found that the compound having a binding activity to the cannabinoid type 2 receptor represented by the formula (I): wherein R' is a group represented by the formula: -Y1-Y2-Y3Ra wherein Y1 is single bond or the like; Y2 is -C(=O)-NH- or the like; Y3 is optionally substituted aryl or the like; R2 is hydrogen or the like; R3 is alkyl or the like; R4 is alkyl or the like; R5 is optionally substituted alkyl or the like; or R3 and R4 taken together with the adjacent atom form cyclic group or the like.