116369-24-5

Basic information

• Product Name: 4-Bromo-5-chloro-2-fluoroaniline
• Synonyms: 4-Bromo-5-chloro-2-fluoroaniline
• CAS NO: 116369-24-5
• Molecular Formula: C₆H₄BrClFN
• Molecular Weight: 224.4580632
• Mol File: 116369-24-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 258.9°C at 760 mmHg
• Flash Point: 110.4°C
• Appearance: /
• Density: 1.809g/cm³
• Vapor Pressure: 0.0134mmHg at 25°C
• Refractive Index: 1.61
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 4-Bromo-5-chloro-2-fluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-5-chloro-2-fluoroaniline(116369-24-5)
• EPA Substance Registry System: 4-Bromo-5-chloro-2-fluoroaniline(116369-24-5)

Safety Data

• Hazardous Substances Data: 116369-24-5(Hazardous Substances Data)

Usage

General Description

4-Bromo-5-chloro-2-fluoroaniline, also known as BCAF, is a chemical compound with the molecular formula C6H4BrClFN. It is an important intermediate in the production of pharmaceuticals and agrochemicals, particularly in the synthesis of various pharmaceuticals and pesticides. BCAF is a white crystalline solid with a high melting point and is sparingly soluble in water. It is toxic if swallowed and can cause skin and eye irritation. BCAF is known to be a potent inhibitor of the enzyme Myeloperoxidase, which has potential implications in the treatment of inflammatory diseases and cancer. Due to its versatile applications, BCAF is an important chemical of interest in the pharmaceutical and agricultural industries.

InChI:InChI=1/C6H4BrClFN/c7-3-1-5(9)6(10)2-4(3)8/h1-2H,10H2

Upstream product

• 2106-05-0 5-chloro-2-fluoroaniline 
• 1027833-17-5 1-bromo-2-chloro-5-fluoro-4-nitrobenzene 
• 201849-15-2 2-bromo-1-chloro-4-fluoro-benzene 

Downstream Products

• 1017777-51-3 2,3-dichloro-6-fluoroaniline 
• 1228376-68-8 4-amino-2-chloro-5-fluoro-benzonitrile 
• 1603584-72-0 4-bromo-5-chloro-2-fluorobenzaldehyde 
• 1332332-75-8 4-[5-chloro-2-fluoro-4-(7-quinolinyl)phenyl]-5-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1332333-76-2 4-(4-bromo-5-chloro-2-fluorophenyl)-5-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1332333-75-1 N-(4-bromo-5-chloro-2-fluorophenyl)-2-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]acetyl}hydrazinecarboxamide 

Relevant articles and documents

N-(HETEROARYL) QUINAZOLIN-2-AMINE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF

The present invention is directed to substituted certain N-(heteroaryl)quinazolin-2-amine derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein J, R3, and R4, are as defined herein, which are potent inhib

SUBSTITUTED AMINOPURINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH

Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.