114748-60-6

Basic information

• Product Name: 5-TFA-ap-2',3'-Dideoxyuridine
• Synonyms: 5-TFA-ap-2',3'-Dideoxyuridine;2',3'-Dideoxy-5-[3-[(trifluoroacetyl)amino]-1-propyn-1-yl]-uridine
• CAS NO: 114748-60-6
• Molecular Formula: C₁₄H₁₄F₃N₃O₅
• Molecular Weight: 361.2732696
• Mol File: 114748-60-6.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-TFA-ap-2',3'-Dideoxyuridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-TFA-ap-2',3'-Dideoxyuridine(114748-60-6)
• EPA Substance Registry System: 5-TFA-ap-2',3'-Dideoxyuridine(114748-60-6)

Safety Data

• Hazardous Substances Data: 114748-60-6(Hazardous Substances Data)

Usage

General Description

5-TFA-ap-2',3'-dideoxyuridine is a chemical compound with antiviral properties that has been synthesized for its potential use in the treatment of viral infections. It is a nucleoside analogue that inhibits the replication of certain viruses by interfering with the process of nucleic acid synthesis. The addition of a trifluoroacetyl group at the 5-position of the uracil base enhances the compound's antiviral activity. The 2',3'-dideoxy modification prevents the compound from being incorporated into the viral DNA or RNA, thereby inhibiting viral replication. Research on 5-TFA-ap-2',3'-dideoxyuridine is ongoing, and it shows promise as a potential antiviral agent for the treatment of various viral infections.

Upstream product

• 14719-21-2 trifluoroacetyl-propargyl amine 
• 105784-83-6 5-Iodo-2',3'-dideoxyuridine 
• 105784-83-6 1-((S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-5-iodo-1H-pyrimidine-2,4-dione 
• 130532-27-3 4-Methyl-benzoic acid (2S,5R)-5-(4-hydroxy-5-iodo-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 130532-28-4 4-Methyl-benzoic acid (2S,5R)-5-{4-hydroxy-2-oxo-5-[3-(2,2,2-trifluoro-acetylamino)-prop-1-ynyl]-2H-pyrimidin-1-yl}-tetrahydro-furan-2-ylmethyl ester 
• 5983-09-5 2',3'-Dideoxyuridine 

Relevant articles and documents

A ligand-free solid-supported system for Sonogashira couplings: Applications in nucleoside chemistry

A mild heterogeneous, ligand-free protocol for Sonogashira and Heck couplings has been developed and used to access several biologically important deoxynucleoside derivatives in a facile manner. The Royal Society of Chemistry 2005.

Alkynylamino-nucleotides

Alkynylamino-nucleotides and labeled alkynylaminonucleotides useful, for example, as chain terminating substrates for DNA sequencing are provided along with several key intermediates and processes for their preparation. For some applications, longer, hydrophilic linkers are provided.

Alkynylamino-nucleotides

Alkynylamino-nucleotides and labeled alkynylamino-nucleotides useful, for example, as chain terminating substrates for DNA sequencing are provided along with several key intermediates and processes for their preparation.