1145938-00-6

Basic information

• Product Name: C₁₄H₂₁N₅O₇
• Synonyms: C₁₄H₂₁N₅O₇
• CAS NO: 1145938-00-6
• Molecular Weight: 371.35
• Mol File: 1145938-00-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₄H₂₁N₅O₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₂₁N₅O₇(1145938-00-6)
• EPA Substance Registry System: C₁₄H₂₁N₅O₇(1145938-00-6)

Safety Data

• Hazardous Substances Data: 1145938-00-6(Hazardous Substances Data)

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 1189096-56-7 4-((2-(2-(2-azidoethoxy)ethoxy)ethyl)amino)-4-oxobutanoic acid 

Downstream Products

• 1145938-02-8 C₃₇H₅₇N₁₃O₁₁ 
• 1186133-35-6 C₆₉H₁₀₀N₂₂O₁₇ 

Relevant articles and documents

β-Lactam-based approach for the chemical programming of aldolase antibody 38C2

Irreversible chemical programming of monoclonal aldolase antibody (mAb) 38C2 has been accomplished with β-lactam-equipped targeting modules. A model study was first performed with β-lactam conjugated to biotin. This conjugate efficiently and selectively modified the catalytic site lysine (LysH93) of mAb 38C2. We then conjugated a β-lactam to a cyclic-RGD peptide to chemically program mAb 38C2 to target integrin receptors αvβ3 and αvβ5. The chemically programmed antibody bound specifically to the isolated integrin receptor proteins as well as the integrins expressed on human melanoma cells. This approach provides an efficient and versatile solution to irreversible chemical programming of aldolase antibodies.