114578-70-0

Basic information

• Product Name: 6-Acetylpyridine-2-carboxylic acid ethyl ester
• Synonyms: 6-Acetylpyridine-2-carboxylic acid ethyl ester;ethyl 6-acetylpyridine-2-carboxylate;6-ACETYL-PICOLINIC ACID ETHYL ESTER;Ethyl 6-acetyl-2-pyridinecarboxylate;ethyl 6-acetylpicolinate;2-Pyridinecarboxylic acid, 6-acetyl-, ethyl ester
• CAS NO: 114578-70-0
• Molecular Formula: C₁₀H₁₁NO₃
• Molecular Weight: 193.19924
• Product Categories: Esters;Pyridines
• Mol File: 114578-70-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 50.0-51.5 °C
• Boiling Point: 329.615 °C at 760 mmHg
• Flash Point: 153.146 °C
• Appearance: /
• Density: 1.146 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.514
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 0.97±0.10(Predicted)
• CAS DataBase Reference: 6-Acetylpyridine-2-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Acetylpyridine-2-carboxylic acid ethyl ester(114578-70-0)
• EPA Substance Registry System: 6-Acetylpyridine-2-carboxylic acid ethyl ester(114578-70-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 114578-70-0(Hazardous Substances Data)

Usage

General Description

6-Acetylpyridine-2-carboxylic acid ethyl ester is a chemical compound that is commonly used in the manufacturing of pharmaceuticals and other industrial products. It is a derivative of pyridine, a heterocyclic compound, and contains an acetyl group and an ethyl ester group. This chemical is known for its unique properties, including its ability to act as a chelating agent and form complexes with metal ions. It is also used as a building block in organic synthesis and as a reagent in chemical reactions. 6-Acetylpyridine-2-carboxylic acid ethyl ester is a valuable chemical compound with various applications in the pharmaceutical and industrial sectors.

InChI:InChI=1/C10H11NO3/c1-3-14-10(13)9-6-4-5-8(11-9)7(2)12/h4-6H,3H2,1-2H3

Upstream product

• 114578-64-2 ethyl 4a,7-dihydro-6-methyl-4H-furo<2,3-e>-1,2-oxazine-3-carboxylate 
• 15658-60-3 diethyl-2,6-pyridinedicarbonyl ester 
• 141-78-6 ethyl acetate 
• 108-48-5 2,6-dimethylpyridine 
• 499-83-2 Pyridine-2,6-dicarboxylic acid 
• 1115589-07-5 C₁₃H₁₅NO₅ 
• 98143-38-5 ethyl 3-bromo-2-hydroxyiminopropanoate 
• 534-22-5 2-methylfuran 

Downstream Products

• 122637-39-2 6-acetylpyridine-2-carboxylic acid 
• 1204421-58-8 6-acetyl-N-(2,6-dimethylphenyl)pyridine-2-carboxamide 
• 1201986-36-8 6-(1-(2-nitrophenylsulfonamido)ethyl)piperidine-2-carboxylic acid 
• 887258-90-4 (2-carbethoxy-6-[1-[(2,4,6-trimethylphenyl)imino]-ethyl]pyridine) 
• 850583-56-1 2-carbethoxy-6-[1-((2,6-diisopropylphenyl)imino)ethyl]pyridine 
• 1280220-45-2 2-(2,6-Et₂C₆H₃N=CMe)-6-{(HO)CMe₂}C₆H₃N 
• 850583-55-0 (2-carbethoxy-6-[1-[(2,6-diethylphenyl)imino]-ethyl]pyridine) 
• 956585-19-6 (E)-2,6-dibromo-N-(1-(6-(quinoxalin-2-yl)pyridin-2-yl)ethylidene)benzeneamine 
• 956585-17-4 (E)-2,6-dichloro-N-(1-(6-(quinoxalin-2-yl)pyridin-2-yl)ethylidene)benzeneamine 
• 956585-15-2 (E)-2,6-difluoro-N-(1-(6-(quinoxalin-2-yl)pyridin-2-yl)ethylidene)benzeneamine 
• 956585-21-0 (E)-2,4,6-trimethyl-N-(1-(6-(quinoxalin-2-yl)pyridin-2-yl)ethylidene)benzeneamine 
• 956585-13-0 (E)-2,6-diisopropyl-N-(1-(6-(quinoxalin-2-yl)pyridin-2-yl)ethylidene)benzeneamine 
• 956585-11-8 (E)-2,6-diethyl-N-(1-(6-(quinoxalin-2-yl)pyridin-2-yl)ethylidene)benzeneamine 
• 956585-09-4 (E)-2,6-dimethyl-N-(1-(6-(quinoxalin-2-yl)pyridin-2-yl)ethylidene)benzeneamine 

Relevant articles and documents

Copper(ii)-hydroxide facilitated C-C bond formation: The carboxamido pyridine system: Versus the methylimino pyridine system

A copper(ii)-hydroxide-induced carbon-carbon bond formation reaction is explored with the synthesis of an asymmetric carboxamido-methylimino pyridine Cu(i) complex of [CuI(py(N-CO)(NC-C)ph2Me2)2]- (12). Two imine-methyl groups are coupled to form a bridge

Two novel microwave-promoted reactions between ethyl 6-acetylpyridine-2- carboxylate and aromatic amine/aliphatic amine

The unsymmetric precursor ethyl 6-acetylpyridine-2-carboxylate (3) was synthesized from 2,6-dipiclinic acid (1). On the basis of this precursor, two distinctively different types of compounds were prepared by microwave irradiation under solvent-free condi

Formation of 2-Acetylpyridines by the Base-catalysed Ring Opening of Dihydro-4H-furooxazines

Furo-oxazines (1), which were formed by the addition of nirtrosoalkenes to 2,5-dimethylfuran or 2-methylfuran, reacted with 1,8-diazabicycloundec-7-ene (DBU) to give 2-acetylpyridines (2).The reaction is postulated to involve an initial base-cataly