114420-67-6 Usage
Description
Brusatol is a natural quassinoid that demonstrates potential therapeutic use in cancer models through the inhibition of Nuclear factor erythroid 2-related factor 2 (Nrf2). It is capable of inducing a variety of biological effects and has shown promise in enhancing the efficacy of chemotherapy by targeting the Nrf2-mediated defense mechanism.
Uses
Used in Anticancer Applications:
BRUSATOL is used as an anticancer agent for enhancing the efficacy of chemotherapy. It inhibits the Nrf2-mediated defense mechanism, leading to a rapid and transient inhibition of Nrf2 signaling and sensitizing mammalian cells to chemical toxicity. Additionally, Brusatol overcomes chemoresistance through the inhibition of protein translation.
Used in Drug Delivery Systems:
While the provided materials do not specifically mention the use of Brusatol in drug delivery systems, its role in enhancing chemotherapy efficacy and overcoming chemoresistance implies that it could be a valuable component in the development of novel drug delivery systems targeting cancer cells.
Check Digit Verification of cas no
The CAS Registry Mumber 114420-67-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,4,2 and 0 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 114420-67:
(8*1)+(7*1)+(6*4)+(5*4)+(4*2)+(3*0)+(2*6)+(1*7)=86
86 % 10 = 6
So 114420-67-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H26O11/c1-11(22)28-9-14(30-20-19(27)18(26)17(25)15(8-21)31-20)10-29-16(24)7-4-12-2-5-13(23)6-3-12/h2-7,14-15,17-21,23,25-27H,8-10H2,1H3/b7-4+/t14-,15?,17?,18?,19?,20?/m0/s1
