114218-35-8 Usage
Description
(-)-Metoprolol hydrochloride is a potent beta-adrenergic blocking agent, one of the two enantiomers of the racemic mixture known as metoprolol hydrochloride. It is primarily used in the treatment of cardiovascular conditions due to its ability to block the action of certain natural chemicals in the body, such as epinephrine, on the heart and blood vessels. This action results in a lowered heart rate, reduced blood pressure, and decreased strain on the heart. The (-)-enantiomer is more effective in this regard compared to its counterpart, making it a preferred choice in medical applications.
Used in Pharmaceutical Industry:
(-)-Metoprolol hydrochloride is used as an antihypertensive agent for the treatment of hypertension, as it helps to lower blood pressure by reducing the force and rate of heart contractions.
(-)-Metoprolol hydrochloride is used as an anti-anginal agent for the treatment of angina pectoris, aiding in the reduction of chest pain and improving blood flow to the heart.
(-)-Metoprolol hydrochloride is used as a heart failure treatment to manage and alleviate symptoms associated with heart failure, by reducing the workload on the heart and improving its function.
Common side effects associated with the use of (-)-Metoprolol hydrochloride include dizziness, tiredness, and a slow heartbeat. It is available in various forms such as tablets, extended-release tablets, and injection, and is commonly prescribed under the brand names Lopressor and Toprol XL.
Check Digit Verification of cas no
The CAS Registry Mumber 114218-35-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,2,1 and 8 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 114218-35:
(8*1)+(7*1)+(6*4)+(5*2)+(4*1)+(3*8)+(2*3)+(1*5)=88
88 % 10 = 8
So 114218-35-8 is a valid CAS Registry Number.
114218-35-8Relevant articles and documents
Kinetic resolution of aryl glycidyl ethers : A practical synthesis of optically pure β-blocker - S-metoprolol
Gurjar, Mukund K.,Sadalapure, Kashinath,Adhikari, Susanta,Sarma, Bugga V. N. B. S.,Talukdar, Arindam,Chorghade, Mukund S.
, p. 1471 - 1476 (2007/10/03)
Kinetic resolution of (±)-aryl glycidyl ethers using (R,R)-salen Co(III)OAc and water provided enantiomerically pure arylglycidyl ether and 1-arylglycerol derivatives with high enantiomeric excess. Application of this approach to (S)-metoprolol has been d
Highly efficient asymmetric hydrogenation of amino ketone derivatives leading to practical syntheses of (S)-propranolol and related compounds
Takahashi, Hisashi,Sakuraba, Shunji,Takeda, Hideo,Achiwa, Kazuo
, p. 5876 - 5878 (2007/10/02)
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