114192-42-6Relevant articles and documents
METHOD FOR THE SYNTHESIS OF A RAMIPRIL INTERMEDIATE
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Page/Page column 12, (2010/05/14)
The present invention relates to a process for the preparation of octahydrocyclopenta[b]pyrrole-2-carboxylic acid and esters thereof of general formula (1) in the presence of a cobalt and/or nickel comprising catalyst and to the use of compounds of general formula (1) in the synthesis of ramipril.
NOVEL CARBAMOYLGLYCINE DERIVATIVES
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Page/Page column 14, (2009/05/28)
The present invention relates to carbamoylglycine derivatives, a process for the preparation of carbamoylglycine derivatives and the use of carbamoylglycine derivatives in the preparation of enantiomerically enriched α-amino acids. Furthermore, the present invention relates to the preparation of pharmaceutically active products such as perindopril and ramipril using the novel carbamoylglycine derivatives.
Expeditious synthesis of ramipril: An angiotensin converting enzyme (ACE) inhibitor
Malakondaiah, Golla China,Gurav,Reddy, Lekkala Amarnath,Babu, Karrothu Srihari,Bhaskar, Bolugoddu Vijaya,Reddy, Padi Pratap,Bhattacharya, Apurba,Anand, Ramasamy Vijaya
, p. 1737 - 1744 (2008/09/21)
We document an efficient and cost-effective synthesis of ramipril 1 utilizing (i) an environmentally benign process for the esterification of racemic 2-aza-bicyclo-[3.3.0]-octane-3-carboxylic acid hydrochloride 2 using boric acid as a catalyst and (ii) a robust resolution process for the synthesis of 3a by means of inexpensive and recyclable L-(+)-mandelic acid as key steps. Copyright Taylor & Francis Group, LLC.