1139889-93-2 Usage
Description
6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline, also known as Golgicide A, is a cell-permeable quinoline compound that selectively targets the cis-Golgi ArfGEF GBF1. It is characterized by its ability to reversibly inhibit GBF1-mediated cellular vesicle trafficking, making it a valuable tool for studying the role of GBF1 in cellular processes.
Uses
Used in Cellular Research:
6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline is used as a research tool for studying the function of GBF1 in cellular vesicle trafficking. Its selective inhibition of GBF1 allows researchers to investigate the role of this protein in various cellular processes without affecting other ArfGEFs like BIG1/2.
Used in Drug Development:
6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline is used as a potential therapeutic agent for conditions related to abnormal cellular vesicle trafficking. By inhibiting GBF1, it may help in the development of treatments for diseases characterized by disrupted vesicle transport.
Used in Endocytic/Retrograde Transport Studies:
6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline is used as an inhibitor of GBF1-dependent retrograde transport in endocytic studies. It has been shown to completely prevent Vero cells from Stx-induced inhibition of cellular protein synthesis, highlighting its potential in understanding the transport of bacterial toxins and their effects on cellular processes.
Used in Pharmaceutical Industry:
6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline is used as a lead compound for the development of new drugs targeting GBF1. Its specificity and reversibility make it an attractive candidate for further optimization and potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1139889-93-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,3,9,8,8 and 9 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1139889-93:
(9*1)+(8*1)+(7*3)+(6*9)+(5*8)+(4*8)+(3*9)+(2*9)+(1*3)=212
212 % 10 = 2
So 1139889-93-2 is a valid CAS Registry Number.
1139889-93-2Relevant articles and documents
Distinct biological effects of golgicide a derivatives on larval and adult mosquitoes
MacK, Daniel J.,Isoe, Jun,Miesfeld, Roger L.,Njardarson, Jon T.
supporting information; experimental part, p. 5177 - 5181 (2012/09/07)
A collection of Golgicide A (GCA) analogs has been synthesized and evaluated in larval and adult mosquito assays. Commercially available GCA is a mixture of four compounds. One enantiomer (GCA-2) of the major diastereomer in this mixture was shown to be responsible for the unique activity of GCA. Structure-activity studies (SAR) of the GCA architecture suggested that the pyridine ring was most easily manipulated without loss or gain in new activity. Eighteen GCA analogs were synthesized of which five displayed distinct behavior between larval and adult mosquitos, resulting in complete mortality of both Aedes aegypti and Anopheles stephensi larvae. Two analogs from the collection were shown to be distinct from the rest in displaying high selectivity and efficiency in killing An. stephensi larvae.
