113952-21-9 Usage
Description
10-Acetyloxy Oxcarbazepine is an intermediate compound used in the preparation of Carbamazepine metabolites, which are essential in the pharmaceutical industry. It is a yellow-orange solid with unique chemical properties that make it a valuable component in the synthesis of various drugs.
Uses
Used in Pharmaceutical Industry:
10-Acetyloxy Oxcarbazepine is used as an intermediate in the synthesis of Carbamazepine metabolites for the development of medications that target specific health conditions. Its role in the production process is crucial, as it helps create the final drug product with desired therapeutic effects.
Used in Drug Development:
As a key intermediate, 10-Acetyloxy Oxcarbazepine is utilized in the research and development of new drugs, particularly those related to Carbamazepine. Its chemical properties allow for further modification and optimization of the final drug product, potentially leading to improved efficacy and safety profiles.
Used in Quality Control and Analysis:
10-Acetyloxy Oxcarbazepine is also employed in the quality control and analysis of pharmaceutical products containing Carbamazepine metabolites. Its presence and purity can be assessed through various analytical techniques, ensuring the overall quality and consistency of the final drug product.
Check Digit Verification of cas no
The CAS Registry Mumber 113952-21-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,9,5 and 2 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 113952-21:
(8*1)+(7*1)+(6*3)+(5*9)+(4*5)+(3*2)+(2*2)+(1*1)=109
109 % 10 = 9
So 113952-21-9 is a valid CAS Registry Number.
InChI:InChI=1/C17H14N2O4/c1-10(20)23-16-12-7-3-5-9-14(12)19(17(18)22)13-8-4-2-6-11(13)15(16)21/h2-9,16H,1H3,(H2,18,22)
113952-21-9Relevant articles and documents
Complementation of biotransformations with chemical C-H oxidation: Copper-catalyzed oxidation of tertiary amines in complex pharmaceuticals
Genovino, Julien,Luetz, Stephan,Sames, Dalibor,Toure, B. Barry
supporting information, p. 12346 - 12352 (2013/09/23)
The isolation, quantitation, and characterization of drug metabolites in biological fluids remain challenging. Rapid access to oxidized drugs could facilitate metabolite identification and enable early pharmacology and toxicity studies. Herein, we compared biotransformations to classical and new chemical C-H oxidation methods using oxcarbazepine, naproxen, and an early compound hit (phthalazine 1). These studies illustrated the low preparative efficacy of biotransformations and the inability of chemical methods to oxidize complex pharmaceuticals. We also disclose an aerobic catalytic protocole (CuI/air) to oxidize tertiary amines and benzylic CH's in drugs. The reaction tolerates a broad range of functionalities and displays a high level of chemoselectivity, which is not generally explained by the strength of the C-H bonds but by the individual structural chemotype. This study represents a first step toward establishing a chemical toolkit (chemotransformations) that can selectively oxidize C-H bonds in complex pharmaceuticals and rapidly deliver drug metabolites.
