113933-55-4

Basic information

• Product Name: ethyl 2-<2,3,5-trifluoro-4-(4-methyl-1-piperazinyl)-benzoyl>-3-dimethylaminoacrylate
• Synonyms: ethyl 2-<2,3,5-trifluoro-4-(4-methyl-1-piperazinyl)-benzoyl>-3-dimethylaminoacrylate
• CAS NO: 113933-55-4
• Molecular Weight: 399.413
• Mol File: 113933-55-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 2-<2,3,5-trifluoro-4-(4-methyl-1-piperazinyl)-benzoyl>-3-dimethylaminoacrylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-<2,3,5-trifluoro-4-(4-methyl-1-piperazinyl)-benzoyl>-3-dimethylaminoacrylate(113933-55-4)
• EPA Substance Registry System: ethyl 2-<2,3,5-trifluoro-4-(4-methyl-1-piperazinyl)-benzoyl>-3-dimethylaminoacrylate(113933-55-4)

Safety Data

• Hazardous Substances Data: 113933-55-4(Hazardous Substances Data)

Upstream product

• 94695-48-4 2,3,4,5-tetrafluorobenzoyl chloride 
• 924-99-2 ethyl 3-(dimethylamino)acrylate 
• 108860-30-6 ethyl 2,3,5-trifluoro-4-(4-methyl-1-piperazinyl)-benzoyl acetate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 100986-85-4 levofloxacin 
• 177472-30-9 C₂₀H₂₄FN₃O₄ 
• 177472-28-5 (S)-ethyl 3-(1-hydroxypropan-2-ylamino)-2-(2,3,5-trifluoro-4-(4-methylpiperazin-1-yl)benzoyl)acrylate 
• 106017-08-7 Rufloxacin hydrochloride 
• 138944-12-4 ethyl 2-<2,3,5-trifluoro-4-(4-methyl-1-piperazinyl)-benzoyl>-3-(1-mercaptoeth-2-ylamino)-acrylate 

Relevant articles and documents

Preparation method of levofloxacin and intermediates thereof

The invention relates to a preparation method of levofloxacin and intermediates thereof, and belongs to the field of medicinal chemistry. The preparation method comprises the following steps of: carrying out amino substitution and ring closing reaction on a fluorine-substituted substrate to integrate a plurality of intermediates into a one-pot reaction, and hydrolyzing under acidic conditions to obtain levofloxacin. According to the method, the reaction operation is simplified, the production period is greatly shortened, multiple times of after-treatment are not needed, emission of three wastes is reduced, the method is more environmentally friendly, the reaction yield is increased by about 20% compared with the prior art, and the method is suitable for industrial amplification.