113886-71-8 Usage
Description
N4-Acetyl-2'-O-Methyl-cytidine is a modified nucleoside that plays a significant role in the field of molecular biology and chemistry. It is characterized by the presence of an acetyl group at the N4 position and a methyl group at the 2'-O position of the cytidine molecule. This modification contributes to its unique properties and potential applications in various industries.
Uses
Used in Synthesis of Functionalized Oligonucleotides:
N4-Acetyl-2'-O-Methyl-cytidine is used as a key building block for the synthesis of functionalized oligonucleotides. The expression is: N4-Acetyl-2'-O-Methyl-cytidine is used as a building block for the synthesis of functionalized oligonucleotides for its unique structural properties that allow for the creation of novel oligonucleotide sequences with specific functions and applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N4-Acetyl-2'-O-Methyl-cytidine is used as a starting material for the development of new drugs, particularly those targeting genetic disorders and diseases related to nucleic acid metabolism. The expression is: N4-Acetyl-2'-O-Methyl-cytidine is used as a starting material for drug development in the pharmaceutical industry for its potential in creating novel therapeutic agents.
Used in Research and Development:
N4-Acetyl-2'-O-Methyl-cytidine is also utilized in research and development for studying the structure-function relationships of nucleic acids and their interactions with proteins and other biomolecules. The expression is: N4-Acetyl-2'-O-Methyl-cytidine is used as a research tool for studying nucleic acid interactions and structure-function relationships in the field of molecular biology.
Check Digit Verification of cas no
The CAS Registry Mumber 113886-71-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,8,8 and 6 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 113886-71:
(8*1)+(7*1)+(6*3)+(5*8)+(4*8)+(3*6)+(2*7)+(1*1)=138
138 % 10 = 8
So 113886-71-8 is a valid CAS Registry Number.
113886-71-8Relevant articles and documents
Improved synthetic approaches toward 2'-O-methyl-adenosine and guanosine and their N-acyl derivatives
Beigelman, Leonid,Haeberli, Peter,Sweedler, David,Karpeisky, Alexander
, p. 1047 - 1056 (2007/10/03)
We developed several improved approaches toward 2'-O-methyl adenosine and guanosine and their N-acyl derivatives. (a) Transglycosylation of N4- acetyl-5', 3'-di-O-acetyl-2'-O-methyl cytidine with N6-Bz-adenine provided N6-benzoyl-5'3'-di-O-acetyl-2'-O-methyl adenosine in 50% yield. (b) Regioselective methylation of 2-amino-6-chloro purine riboside with MeI/NaH followed by hydrolysis provided 2'-O-Me-guanosine in high yield. The same 2'- O-Me-precursor was transformed into 2'-O-Me-adenosine in 58% yield. (c) Very efficient transformation of 2,6-diamino-purine riboside into N2-isobutyryl (isopropylphenoxyacetyl) 2'-O-Me-guanosine through methylation of 5',3'-O- TIPDSi derivative followed by selective N2-acylation, deamination and desylilation provided target compounds in 70% combined yield. (d) Mg2+ and Ag+ directed methylation of N1-Bzl-guanosine proceeded in >80% yield with ratio of 2'-O-Me-3'-O-Me=9:1. The same methylation of adenosine with Ag+ and Sr2+ acetylacetonates provided 2'-O-Me-adenosine in 75-80% yield. (C) 2000 Elsevier Science Ltd.
Alternate approaches to the synthesis of 2'-O-Me nucleosides
Beigelman,Karpeisky,Matulic-Adamic,Usman
, p. 421 - 425 (2007/10/02)
Three different approaches to the synthesis of 2'-O-methyl nucleosides starting from the corresponding nucleoside or commercially available 1,2:5,6-di-O-isopropylidene-α-D-allofuranose 1 are described.
