112935-94-1Relevant articles and documents
A amine reduction method
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Paragraph 0011; 0039; 0041; 0042; 0044, (2017/04/25)
The invention provides a preparation method for an impurity reference substance for producing bambuterol and belongs to the technical field of pharmacy. The method comprises the following steps: introducing hydrogen into the raw material to reduce in the presence of acid and a catalyst to prepare a product, wherein the acid is selected from hydrochloric acid, phosphoric acid, acetic acid, formic acid, trifluoroacetic acid, benzenesulfonic acid, p-toluenesulfonic acid and malic acid; and the pressure of the hydrogen is lower than or equal to 180kPa.