112790-83-7

Basic information

• Product Name: (S)-3-(2'-hydroxy-2'-phenylethyl)-2-thiazolidinimine
• Synonyms: (S)-3-(2'-hydroxy-2'-phenylethyl)-2-thiazolidinimine
• CAS NO: 112790-83-7
• Molecular Weight: 222.311
• Mol File: 112790-83-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-3-(2'-hydroxy-2'-phenylethyl)-2-thiazolidinimine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(2'-hydroxy-2'-phenylethyl)-2-thiazolidinimine(112790-83-7)
• EPA Substance Registry System: (S)-3-(2'-hydroxy-2'-phenylethyl)-2-thiazolidinimine(112790-83-7)

Safety Data

• Hazardous Substances Data: 112790-83-7(Hazardous Substances Data)

Upstream product

• 848186-80-1 (S)-2-((tert-butyldimethylsilyl)oxy)-2-phenylethanamine 
• 121673-60-7 2-aminoacetophenone hydrochloride 
• 848186-81-2 N-(2-chloroethyl)-2-tert-butyldimethylsilyloxy-2-phenylethanamine 
• 186343-35-1 (S)-5-phenyl-1,3-oxazolidine-2-one 
• 56613-81-1 (S)-2-Amino-1-phenyl-1-ethanol 
• 333-20-0 potassium thioacyanate 
• 121673-61-8 N-(2-chloroethylamino)-1-phenyl-1-ethanol 
• 20405-96-3 (S)-1-phenyl-2aminoethanol hydrochloride 
• 17899-33-1 2-imino-3-(2'-hydroxy-2'-phenylethyl)thiazolidine hydrochloride 

Downstream Products

• 79514-28-6 iso-tetramisole 
• 14769-73-4 Levamisole 

Relevant articles and documents

A new facile chemoenzymatic synthesis of levamisole

An efficient and facile chemoenzymatic synthesis of levamisole by employing lipase-mediated resolution of 3-hydroxy-3-phenylpropanenitrile followed by its conversion to β-amino alcohol as the key intermediate is described.

The Optical Resolution of 3-(2'-Hydroxy-2'-phenylethyl)-2-thiazolidinimine, and the Crystal Structure of the (2R,3R)-O,O'-Dibenzoyl Hydrogen Tartrate Salt of the (S)-(+)-Enantiomer

The optical resolution has been investigated for 3-(2'-hydroxy-2'-phenylethyl)-2-thiazolidinimine with (2R,3R)-O,O'-dibenzoyltartaric acid.The most effective separation of the enantiomers is attained if the resolution is performed in methanol with the reactants in a 1:1 ratio.The crystal structure at 122 K of the precipitating salt (C11H15N2OS+ * C18H13O-8 * CH3OH) has been determined by X-ray diffraction methods.Crystals are monoclinic, space group P21, with a=7.5831(9), b=12.5698(14), c=15.835(2) Angstroem, β=101.980(9) deg, V=1476.5(3) Angstroem3, Z=2, Dx=1.378 g cm-3, μ=15.00 cm-1.The crystal structure refined to R=0.0255 for 6046 contributing reflections, established that the (+)D rotation of the cation corresponds to the S-enantiomer.The strongest intermolecular interactions are the short hydrogen bonds between the carboxylic acid and the carboxylate groups of anions related by translational symmetry along the a-axis.Methanol also plays a significant role in the hydrogen-bonding system.The packing mode in the present structure is compared to that of the mono-, dibenzoyl- and di-p-toluoyl hydrogen tartrates found in the Cambridge Structural Database.