112163-03-8

Basic information

• Product Name: 2-METHOXY-3-NITRO-6-PICOLINE
• Synonyms: 2-METHOXY-3-NITRO-6-PICOLINE;2-methoxy-3-nitro-6-methylpyridine;2-METHOXY-3-NITRO-6-ICOLINE;2-Methoxy-6-methyl-3-nitropyridine;6-Methoxy-5-nitropicoline;Methoxy-6-Methyl-3-nitropyridine
• CAS NO: 112163-03-8
• Molecular Formula: C₇H₈N₂O₃
• Molecular Weight: 168.15
• Product Categories: Pyridine;Pyridines;Boronic Acid
• Mol File: 112163-03-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 57-58 °C(Solv: hexane (110-54-3))
• Boiling Point: 272.185 °C at 760 mmHg
• Flash Point: 118.413 °C
• Appearance: /
• Density: 1.248 g/cm³
• Vapor Pressure: 0.0103mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: 2-8°C
• PKA: 0.09±0.10(Predicted)
• CAS DataBase Reference: 2-METHOXY-3-NITRO-6-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-3-NITRO-6-PICOLINE(112163-03-8)
• EPA Substance Registry System: 2-METHOXY-3-NITRO-6-PICOLINE(112163-03-8)

Safety Data

• Hazardous Substances Data: 112163-03-8(Hazardous Substances Data)

Usage

General Description

2-Methoxy-3-nitro-6-picoline is a chemical compound with the molecular formula C7H8N2O3. It is also known as 6-methoxynicotinic acid. This yellow crystalline substance is commonly used as an intermediate in the production of pharmaceuticals, pesticides, and other organic compounds. It is also known for its potential application as a corrosion inhibitor in petroleum refining. 2-Methoxy-3-nitro-6-picoline has a molecular weight of 168.15 g/mol and a melting point of 72-74°C. It is categorized as a hazardous substance and should be handled with care to avoid adverse health effects.

InChI:InChI=1/C7H8N2O3/c1-5-3-4-6(9(10)11)7(8-5)12-2/h3-4H,1-2H3

Upstream product

• 67-56-1 methanol 
• 19346-45-3 2-fluoro-3-nitro-6-methylpyridine 
• 39745-39-6 6-methyl-3-nitropyridin-2-one 
• 124-41-4 sodium methylate 
• 56057-19-3 2-chloro-6-methyl-3-nitropyridine 
• 21901-29-1 6-amino-5-nitro-2-picoline 
• 123-54-6 acetylacetone 
• 15579-58-5 5-nitro-4-methoxypyrimidine 

Downstream Products

• 186413-79-6 3-amino-2-methoxy-6-methylpyridine 

Relevant articles and documents

Phenacylation of 6-methyl-beta-nitropyridin-2-ones and further heterocyclization of products

Reaction between the derivatives of 6-methyl-beta-nitropyridin-2-one and phenacyl bromides was studied, and the yields observed were extremely low. The pyridones were converted via chloropyridines to methoxyderivatives, which were N-phenacylated. N-Phenacyl derivatives of 4,6-dimethyl-5-nitropyridin-2-one under the action of base gave 5-hydroxy-8-nitroindolizine and under acidic conditions gave 5-methyl-6-nitrooxazole[3,2-a]pyridinium salt, which underwent recycization with MeONa to 5-methoxy-8-nitroindolizine.

ALKOXY-SUBSTITUTED PYRIDINYL DERIVATIVES AS LPA1 RECEPTOR ANTAGONISTS AND THEIR USE IN THE TREATMENT OF FIBROSIS

The present invention relates to pyridinyl derivatives of Formula (I) Formula (I) wherein R1, R2, R3, R4, R5, R6, Ar1, L, W, Z, m and n are as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as LPA1 receptor modulators.