1120357-36-9Relevant articles and documents
Fast, acid-free, and selective lactamization of lactones in ionic liquids
Orrling, Kristina M.,Wu, Xiongyu,Russo, Francesco,Larhed, Mats
, p. 8627 - 8630 (2008)
(Chemical Equation Presented) A fast and acid-free one-pot 0.2-30 mmol microwave methodology for direct ionic liquid-mediated preparation of lactams from lactones and primary amines has been developed. The protocol was investigated with a wide range of primary amines and a handful of lactones, including substrates with acid-sensitive substituents. Both γ-lactams and δ-lactams were, despite the complete absence of a Bronsted acid, obtained in useful to excellent yields after only 35 min of microwave processing.