1120-88-3 Usage
Description
4-Methylpyridazine is an organic compound with the chemical formula C6H6N2. It is a clear yellow liquid and is structurally related to bipyridine cardiotonics. The compound has been investigated through various reactions, such as its reaction with methyl iodide, which has been studied using NMR spectra. Additionally, solvent-free oxidation of 4-methylpyridazine by acetyl peroxyborate, peracetic acid, and hydrogen peroxide has been reported.
Uses
Used in Pharmaceutical Industry:
4-Methylpyridazine is used as a chemical intermediate for the synthesis of various pyridazine derivatives. These derivatives are structurally related to bipyridine cardiotonics, which are compounds that have a positive inotropic effect on the heart, making them useful in the treatment of heart failure and other cardiovascular conditions.
Used in Chemical Research:
4-Methylpyridazine serves as a valuable compound in chemical research, particularly in the study of its reactions with other substances. The investigation of its reaction with methyl iodide using NMR spectra provides insights into the structural and chemical properties of the resulting products. This information can be useful for the development of new compounds and applications in various fields.
Used in Oxidation Reactions:
4-Methylpyridazine is also used in oxidation reactions, such as its solvent-free oxidation by acetyl peroxyborate, peracetic acid, and hydrogen peroxide. These reactions can lead to the formation of new compounds with different properties and potential applications in various industries, including pharmaceuticals, materials science, and environmental science.
Check Digit Verification of cas no
The CAS Registry Mumber 1120-88-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,2 and 0 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1120-88:
(6*1)+(5*1)+(4*2)+(3*0)+(2*8)+(1*8)=43
43 % 10 = 3
So 1120-88-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H6N2/c1-5-2-3-6-7-4-5/h2-4H,1H3
1120-88-3Relevant articles and documents
METHOD FOR RAPIDLY METHYLATING HETEROAROMATIC ARENE AND METHOD FOR PRODUCING TRACER FOR USE IN PET
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Page/Page column 5-6, (2011/11/06)
Provided is a method whereby a heteroaromatic ring aryl can be very rapidly methylated at a high yield. In an N-alkyl-2-pyrrolidinone, a heteroaromatic ring aryltrialkylstannan is cross-coupled with methyl iodide in the presence of a palladium complex, a phosphine ligand, a cuprous halide, a carbonic acid salt and/or an alkali metal fluoride to thereby rapidly methylate the heteroaromatic ring aryl. (Formula shows a case wherein the heteroaromatic ring aryl is a pyridyl group.)
SYNTHESES AND REACTIONS OF PYRIDAZINE DERIVATIVES XX STUDIES ON THE RADICAL METHYLATION OF THE 1,2-DIAZINE SYSTEM
Heinisch, Gottfried,Loutsch, Gerhard
, p. 1395 - 1402 (2007/10/02)
Protonated pyridazines (1,2,3) on reaction with methyl radical (generated by oxidative decarboxylation of acetic acid or by redox reaction of t-BuOOH/FeSO4*7H2O) are shown mainly to be attacked at positions β to the nitrogen atoms.However, formation of compounds 2, 4, 5, 6, 8, 9 and 10 indicates lower degree of regioselectivity compared with homolytic benzylation or acylation of the 1,2-diazine system.Synthesis of ethyl 5-styryl-4-pyridazinecarboxylates(13,14) was achieved by homolytic methylation of ethyl 4-pyridazinecarboxylate(11) followed by condensation with aromatic carbaldehydes.
