1118807-13-8

Basic information

• Product Name: KY0211
• Synonyms: KY0211;KY02111;KY02111 / KY-02111;N-(6-Chloro-2-benzothiazolyl)-3,4-dimethoxybenzenepropanamide;Benzenepropanamide, N-(6-chloro-2-benzothiazolyl)-3,4-dimethoxy-;KY0211 N-(6-Chloro-2-benzothiazolyl)-3,4-dimethoxybenzenepropanamide;N-(6-Chloro-2-benzothiazolyl)-3,4-dimethoxybenzenepropanamide KY02111;KY02111, >=98%
• CAS NO: 1118807-13-8
• Molecular Formula: C18H17ClN2O3S
• Molecular Weight: 376.85718
• EINECS: -0
• Product Categories: API;Inhibitors
• Mol File: 1118807-13-8.mol
• Article Data: 1

Chemical Properties

• Appearance: white to beige/
• Density: 1.362±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: DMSO: soluble10mg/mL, clear
• PKA: 9.92±0.70(Predicted)
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
• CAS DataBase Reference: KY0211(CAS DataBase Reference)
• NIST Chemistry Reference: KY0211(1118807-13-8)
• EPA Substance Registry System: KY0211(1118807-13-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 46
• WGK Germany: 3
• Hazardous Substances Data: 1118807-13-8(Hazardous Substances Data)

Usage

Description

KY0211, also known as KY-02111, is a compound that promotes cardiac differentiation of human pluripotent stem cells. It inhibits Wnt signaling in a unique manner, different from other Wnt inhibitors. KY0211 is cell permeable and active in vivo, making it a valuable tool for research and potential therapeutic applications in the field of regenerative medicine and cardiology.

Uses

Used in Regenerative Medicine:
KY0211 is used as an inducer for the differentiation of pluripotent stem cells into cardiac muscle. This application is particularly relevant for the development of novel treatments and therapies for various heart diseases and conditions, as well as for research purposes in understanding the mechanisms of cardiac differentiation and regeneration.
Used in Pharmaceutical Research:
KY0211 is used as a research tool for studying the Wnt signaling pathway, which plays a crucial role in various biological processes, including cell differentiation, tissue regeneration, and cancer progression. By inhibiting Wnt signaling in a distinct manner, KY0211 can provide valuable insights into the development of new drugs and therapies targeting the Wnt pathway for various diseases.
Used in Drug Development:
KY0211 can be used in the development of new drugs and therapies for heart diseases, as its ability to induce cardiac differentiation in pluripotent stem cells may lead to the discovery of novel compounds and treatment strategies for conditions such as heart failure, myocardial infarction, and other cardiovascular disorders.

References

1) Minami et al. (2012), A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions; Cell Rep., 2 1448

Relevant articles and documents

PLURIPOTENT STEM CELL CARDIOMYOCYTE DIFFERENTIATION-PROMOTING AGENT

The present invention relates to a composition for promoting differentiation of pluripotent stem cells into cardiac muscle cells, and a method for inducing differentiation of pluripotent stem cells into cardiac muscle cells and a method for preparing cardiac muscle cells.