111605-07-3

Basic information

• Product Name: 1H-1-Benzazepine-3-carboxylic acid, 2,3,4,5-tetrahydro-4-(4-methoxyphenyl)-2-oxo-6-(trifluoromethyl)-
• CAS NO: 111605-07-3
• Molecular Formula: C19H16F3NO4
• Molecular Weight: 379.336
• Mol File: 111605-07-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-1-Benzazepine-3-carboxylic acid, 2,3,4,5-tetrahydro-4-(4-methoxyphenyl)-2-oxo-6-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1-Benzazepine-3-carboxylic acid, 2,3,4,5-tetrahydro-4-(4-methoxyphenyl)-2-oxo-6-(trifluoromethyl)-(111605-07-3)
• EPA Substance Registry System: 1H-1-Benzazepine-3-carboxylic acid, 2,3,4,5-tetrahydro-4-(4-methoxyphenyl)-2-oxo-6-(trifluoromethyl)-(111605-07-3)

Safety Data

• Hazardous Substances Data: 111605-07-3(Hazardous Substances Data)

Upstream product

• 111605-06-2 (3S-trans)-2,3,4,5-Tetrahydro-4-(4-methoxyphenyl)-2-oxo-6-(trifluoromethyl)-1H-1-benzazepine-3-carboxylic acid,methyl ester 
• 111604-99-0 [1-(4-Methoxyphenyl)-2-[2-nitro-6-(trifluoromethyl)phenyl]ethyl]propanedioic acid,dimethyl ester 
• 111605-05-1 [2-(2-amino-6-trifluoromethylphenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid,dimethyl ester 
• 7443-25-6 dimethyl 2-(4-methoxybenzylidene)malonate 
• 6656-49-1 2-methyl-1-nitro-3-(trifluoromethyl)benzene 
• 138383-10-5 1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 

Relevant articles and documents

Benzazepinone calcium channel blockers. 2. Structure-activity and drug metabolism studies leading to potent antihypertensive agents. Comparison with benzothiazepinones

As part of a program to discover potent antihypertensive analogues of diltiazem (3a), we prepared 1-benzazepin-2-ones (4). Benzazepinones competitively displace radiolabeled diltiazem, and show the same absolute stereochemical preferences at the calcium channel receptor protein. Derivatives of 4 containing a trifluoromethyl substituent in the fused aromatic ring show potent and long-acting antihypertensive activity. Studies of the metabolism of 4 lead to the metabolically stable antihypertensive calcium channel blockers 5a and 5c. Benzazepinone 5a is a longer acting and more potent antihypertensive agent than the second generation diltiazem analogue TA-3090 (3e).