110821-33-5

Basic information

• Product Name: ethyl 1-(4-chlorophenyl)-1H-pyrazole-4-carboxylate
• Synonyms: ethyl 1-(4-chlorophenyl)-1H-pyrazole-4-carboxylate;1-(4-Chlorophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester
• CAS NO: 110821-33-5
• Molecular Formula: C₁₂H₁₁ClN₂O₂
• Molecular Weight: 250.68094
• Mol File: 110821-33-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 127-129℃ (ethanol )
• Appearance: /
• CAS DataBase Reference: ethyl 1-(4-chlorophenyl)-1H-pyrazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1-(4-chlorophenyl)-1H-pyrazole-4-carboxylate(110821-33-5)
• EPA Substance Registry System: ethyl 1-(4-chlorophenyl)-1H-pyrazole-4-carboxylate(110821-33-5)

Safety Data

• Hazardous Substances Data: 110821-33-5(Hazardous Substances Data)

Usage

General Description

Ethyl 1-(4-chlorophenyl)-1H-pyrazole-4-carboxylate is a synthetic chemical compound with a molecular formula C12H11ClN2O2. It is a pyrazole derivative, which is a class of organic compounds commonly used in pharmaceuticals and agrochemicals. This specific compound may have various applications due to its unique chemical structure, such as for research purposes or as a building block in the synthesis of other compounds. Its properties and potential uses would likely be determined through further study and experimentation in a laboratory setting.

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Downstream Products

• 138907-80-9 1-(4-chlorophenyl)-1H-pyrazole-4-carboxylic acid 

Relevant articles and documents

Process research, development, and pilot-plant preparation of clofencet, a novel wheat hybridizing agent: Lewis acid-catalyzed reaction of ethyl diazoacetate with 4-chlorophenyl hydrazonoacetaldehyde

Described are studies directed toward the chemical research and development of an alternative synthesis to 9, the penultimate intermediate of clofencet (1), a novel wheat-hybridizing agent. Retrosynthetic analyses as well as the results obtained from feasibility studies are detailed, leading to the successful development of an alternative process. The key features of the novel route are a method for preparing on-scale ethyl diazoacetate (28) in a safe and effective manner, and the Lewis acid-catalyzed reaction of 28 with hydrazonoacetaldehyde 29, affording β-ketoester 30. The synthesis is completed via propionylation of 30, acid-catalyzed cyclization of 31 to pyridazinecarboxylic acid ester 32, followed by saponification and isolation of carboxylic acid 9. The results and challenges of eight pilot-plant runs are reported. The baseline process developed produced over 45 kg of 9 in 43-45% yield.

Design, synthesis, biological evaluation and in silico studies of pyrazole‐based nh2‐acyl oseltamivir analogues as potent neuraminidase inhibitors

Oseltamivir represents one of the most successful neuraminidase (NA) inhibitors in the current anti‐influenza therapy. The 150‐cavity of NA was identified as an additional binding pocket, and novel NA inhibitors have been designed to occupy the 150‐cavity

Electrophotocatalytic SNAr Reactions of Unactivated Aryl Fluorides at Ambient Temperature and Without Base

The electrophotocatalytic SNAr reaction of unactivated aryl fluorides at ambient temperature without strong base is demonstrated.