110588-57-3

Basic information

• Product Name: SAPERCONAZOLE
• Synonyms: SAPERCONAZOLE;(+-)-1-sec-Butyl-4-(p-(4-(p-(((2R*,4S*)-2-(2,4-difluorophenyl)-2-(1H-1 ,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazin yl)phenyl)-delta(sup 2)-1,2,4-triazolin-5-one;4-[4-[4-[4-[[2-(2，4-Difluorophenyl)-2-(1H-1，2，4-triazol-1-yl-methyl)-1，3-dioxolan-4-y1]methoxyl]phenyl]-1-piperazinyl]phenyl]-2，4-dihydrcr2-(1-methylpropyl)-3H-1，2，4-triazol-3-one;R-66905;2-(1H-1,2,4-Triazol-1-ylmethyl)-2-(2,4-difluorophenyl)-4-[[4-[4-[4-[[2-(1-methylpropyl)-2,3-dihydro-3-oxo-4H-1,2,4-triazol]-4-yl]phenyl]piperazin-1-yl]phenoxy]methyl]-1,3-dioxolane;2-sec-Butyl-4-[4-[4-[4-[[2-(1H-1,2,4-triazole-1-ylmethyl)-2-(2,4-difluorophenyl)-1,3-dioxolane-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-3H-1,2,4-triazole-3-one
• CAS NO: 110588-57-3
• Molecular Formula: C35H38F2N8O4
• Molecular Weight: 672.72
• Mol File: 110588-57-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 189.5°
• Boiling Point: 812.5°Cat760mmHg
• Flash Point: 445.2°C
• Appearance: /
• Density: 1.37g/cm³
• Vapor Pressure: 1.81E-26mmHg at 25°C
• Refractive Index: 1.656
• Storage Temp.: 2-8°C
• PKA: 6.47±0.40(Predicted)
• CAS DataBase Reference: SAPERCONAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: SAPERCONAZOLE(110588-57-3)
• EPA Substance Registry System: SAPERCONAZOLE(110588-57-3)

Safety Data

• Hazardous Substances Data: 110588-57-3(Hazardous Substances Data)

Usage

Description

SAPERCONAZOLE is an antifungal compound, which is an analog of Itraconazole (I937500), an orally active antimycotic that is structurally related to Ketoconazole. It possesses potent antifungal properties and is effective against a wide range of fungal infections.

Uses

Used in Pharmaceutical Industry:
SAPERCONAZOLE is used as an antifungal agent for the treatment of various fungal infections. It is particularly effective against Candida and Aspergillus species, which are common causes of invasive fungal infections. The compound works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, leading to the disruption of cell membrane integrity and ultimately causing cell death.
Used in Antifungal Treatments:
SAPERCONAZOLE is used as a therapeutic agent for the management of fungal infections, particularly in immunocompromised patients who are at a higher risk of developing such infections. Its potent antifungal activity makes it a valuable addition to the arsenal of antifungal drugs, offering an alternative treatment option for patients who may not respond well to other antifungal medications.
Used in Research and Development:
SAPERCONAZOLE is also used as a research tool in the study of fungal pathogenesis and the development of new antifungal drugs. Its structural similarity to Itraconazole and Ketoconazole allows researchers to investigate the mechanisms of action and resistance patterns of these drugs, potentially leading to the discovery of novel antifungal agents with improved efficacy and reduced side effects.

InChI:InChI=1/C35H38F2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/m0/s1