110064-50-1

Basic information

• Product Name: 7-Hydroxy-3-(4-hydroxybenzylidene)chroMan-4-one
• Synonyms: 7-Hydroxy-3-(4-hydroxybenzylidene)chroMan-4-one;(E)-2,3-Dihydro-7-hydroxy-3-[(4-hydroxyphenyl)methylene]-4H-1-benzopyran-4-one;(E)-7-Hydroxy-3-(4-hydroxybenzylidene)chroMan-4-one
• CAS NO: 110064-50-1
• Molecular Formula: C16H12O4
• Molecular Weight: 268.26408
• Mol File: 110064-50-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 547.1±50.0 °C(Predicted)
• Appearance: /
• Density: 1.423±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 7.62±0.20(Predicted)
• CAS DataBase Reference: 7-Hydroxy-3-(4-hydroxybenzylidene)chroMan-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Hydroxy-3-(4-hydroxybenzylidene)chroMan-4-one(110064-50-1)
• EPA Substance Registry System: 7-Hydroxy-3-(4-hydroxybenzylidene)chroMan-4-one(110064-50-1)

Safety Data

• Hazardous Substances Data: 110064-50-1(Hazardous Substances Data)

Usage

General Description

7-Hydroxy-3-(4-hydroxybenzylidene)chroman-4-one is a chemical compound that belongs to a class of organic substances referred to as flavonoids, which are widely distributed in the plant kingdom and are commonly found in fruits, vegetables, nuts, seeds, stems, flowers, tea, wine, propolis and honey. One of its key features is the presence of a 2-phenylchromen-4-one (flavone backbone), in which a phenyl group is substituted at the 2-position by a chromen-4-one moiety. The detailed information about its biological properties and potential applications is not clearly defined due to its specific and complex structure. Further comprehensive and detailed scientific studies would be needed to understand more about the properties, uses, and potential benefits of this particular molecule.

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Relevant articles and documents

Synthesis and biological evaluation of 3-benzylidene-4-chromanone derivatives as free radical scavengers and α-glucosidase inhibitors

A series of 3-benzylidene-4-chromanone derivatives (3-20) were synthesized and the structure-activity relationships for antioxidant and α-glucosidase inhibitory activities were evaluated. Among synthesized compounds, compounds 5, 13, 18, which contain catechol moiety, showed the potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity (5: EC50 13 μM; 13: EC50 14 μM; 18: EC50 13 μM). The compounds 12, 14, 18 showed higher α-glucosidase inhibitory activity (12: IC50 15 μM; 14: IC50 25 μM; 18: IC50 28 μM). The compound 18 showed both of potent DPPH radical scavenging and α-glucosidase inhibitory activities. These data suggest that 3-benzylidene-4-chromanone derivatives, such as compound 18, may serve as the lead compound for the development of novel α-glucosidase inhibitors with antioxidant activity.

Synthesis and antioxidant properties of substituted 3-benzylidene-7-alkoxychroman-4-ones

A series of 3-benzylidene-7-alkoxychroman-4-one derivatives were synthesized and evaluated for their antioxidant activities. The antioxidant activity was assessed using three methods, namely, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, ferric