11006-55-6 Usage
Description
Sodium tauroglycocholate, with the chemical name 3α,7α,12α-trihydroxy-5β-cholan-24-oic acid N-(2-hydroxyethyl)glycine salt, is a bile salt derived from the conjugation of taurine with glycocholic acid. It is a naturally occurring component of bile and plays a crucial role in the emulsification and absorption of dietary fats. Sodium tauroglycocholate is known for its amphiphilic properties, which allow it to form micelles and facilitate the transport of lipophilic substances.
Source:
Sodium tauroglycocholate is primarily sourced from the bile of animals, particularly from the liver of cows and pigs. It can also be synthesized chemically or produced through biotransformation processes.
Production Methods:
The production of sodium tauroglycholate involves the conjugation of taurine with glycocholic acid. This can be achieved through chemical synthesis or enzymatic processes. In the enzymatic approach, taurine and glycocholic acid are combined in the presence of a specific enzyme, such as bile salt: amino acid ligase, which catalyzes the formation of the conjugate.
Uses
Used in Pharmaceutical Industry:
Sodium tauroglycholate is used as a permeation enhancer for transdermal drug delivery. It enhances the absorption of drugs through the skin by increasing the permeability of the stratum corneum, the outermost layer of the skin. This allows for the efficient delivery of lipophilic drugs, which would otherwise have limited skin penetration.
Sodium tauroglycholate is used as an excipient in the formulation of pharmaceutical products, particularly for oral and injectable dosage forms. It serves as a solubilizing agent, emulsifier, and stabilizer, improving the physical and chemical stability of drug formulations.
Used in Cosmetics Industry:
In the cosmetics industry, sodium tauroglycholate is used as an emulsifying agent and surfactant. It helps to create stable emulsions and suspensions, ensuring the uniform distribution of ingredients in cosmetic products. This contributes to the product's effectiveness, texture, and overall performance.
Used in Research Applications:
Sodium tauroglycholate is utilized in various research applications, particularly in the study of lipid digestion, absorption, and metabolism. It is also used as a model compound to investigate the interactions between bile salts and biological membranes, as well as their effects on membrane permeability and transport processes.
Check Digit Verification of cas no
The CAS Registry Mumber 11006-55-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,1,0,0 and 6 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 11006-55:
(7*1)+(6*1)+(5*0)+(4*0)+(3*6)+(2*5)+(1*5)=46
46 % 10 = 6
So 11006-55-6 is a valid CAS Registry Number.
InChI:InChI=1/C28H48N2O8S.Na/c1-16(4-7-24(34)30-15-25(35)29-10-11-39(36,37)38)19-5-6-20-26-21(14-23(33)28(19,20)3)27(2)9-8-18(31)12-17(27)13-22(26)32;/h16-23,26,31-33H,4-15H2,1-3H3,(H,29,35)(H,30,34)(H,36,37,38);/q;+1/p-1/t16-,17+,18-,19-,20?,21?,22-,23+,26?,27+,28-;/m1./s1
