110013-21-3

Basic information

• Product Name: Merafloxacin
• Synonyms: Merafloxacin;Merafloxacin [inn]
• CAS NO: 110013-21-3
• Molecular Formula: C19H23F2N3O3
• Molecular Weight: 379.405
• Mol File: 110013-21-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 545.8°Cat760mmHg
• Flash Point: 283.9°C
• Appearance: /
• Density: 1.304g/cm³
• Vapor Pressure: 9.58E-13mmHg at 25°C
• Refractive Index: 1.566
• CAS DataBase Reference: Merafloxacin(CAS DataBase Reference)
• NIST Chemistry Reference: Merafloxacin(110013-21-3)
• EPA Substance Registry System: Merafloxacin(110013-21-3)

Safety Data

• Hazardous Substances Data: 110013-21-3(Hazardous Substances Data)

Usage

General Description

Merafloxacin is a fluoroquinolone antibiotic used in veterinary medicine to treat bacterial infections in dogs and cats. It works by inhibiting the enzymes necessary for bacterial DNA replication, leading to bacterial cell death. Merafloxacin is effective against a wide range of gram-negative and gram-positive bacteria, including those that cause urinary tract infections, skin and soft tissue infections, and respiratory infections. It is typically administered orally or through injection and is generally well-tolerated by animals with few reported side effects. However, it is important to use Merafloxacin with caution and follow the instructions of a veterinarian to avoid the development of antibiotic resistance and potential harmful effects.

InChI:InChI=1/C19H23F2N3O3/c1-3-22-8-11-5-6-24(9-11)17-14(20)7-12-16(15(17)21)23(4-2)10-13(18(12)25)19(26)27/h7,10-11,22H,3-6,8-9H2,1-2H3,(H,26,27)

Upstream product

• 75338-42-0 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 
• 91187-83-6 3-((N-ethylamino)methyl)pyrrolidine 
• 6674-22-2 1,8-diazabicyclo[5.4.0]undec-7-ene 
• 79660-46-1 ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 100501-62-0 ethyl 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate 

Relevant articles and documents

1-Ethyl-7--1-pyrrolidinyl>-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid. New Quinolone Antibacterial with Potent Gram-Positive Activity

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1-Substituted 7--1-pyrrolidinyl>-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acids. New Quantitative Structure-Activity Relationships at N1 for the Quinolone Antibacterials

A series of 18 1-substituted 7--1-pyrrolidinyl>-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (N1 analogues of CI-934) was synthesized and evaluated for antibacterial activity and DNA-gyrase inhibition.Correlations between the inhibition of DNA gyrase and antibacterial potency were established.A quantitative structure-activity relationship (QSAR) was derived by using the antibacterial potency of each of 11 strains of bacteria and the Gram-negative mean.The equations indicated that antibacterial potency was strongly dependent on STERIMOL length and width and the level of unsaturation of the N1 substituent.Some strains also showed a dependence on the presence of heteroatoms (O, N, S) in the N1 group.No significant correlations between gyrase inhibition and correlations of these parameters were found.These QSAR results are discussed in conjunction with the conformational analyses from molecular modeling studies.The substituent that most enhanced the activity of the quinolone in all regards was the cyclopropyl group.This analogue, 1-cyclopropyl-7--1-pyrrolidinyl>-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (PD 117558), demonstrated outstanding broad spectrum activity both in vitro and in vivo when compared to relevant standards.

Antibacterial agents

Novel naphthyridine-, quinoline- and benzoxazine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.