1095559-57-1

Basic information

• Product Name: 4-Chloro-2-cyclobutylquinazoline
• Synonyms: 4-Chloro-2-cyclobutylquinazoline
• CAS NO: 1095559-57-1
• Molecular Formula: C12H11ClN2
• Molecular Weight: 218.68214
• Mol File: 1095559-57-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Chloro-2-cyclobutylquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2-cyclobutylquinazoline(1095559-57-1)
• EPA Substance Registry System: 4-Chloro-2-cyclobutylquinazoline(1095559-57-1)

Safety Data

• Hazardous Substances Data: 1095559-57-1(Hazardous Substances Data)

Upstream product

• 134-20-3 2-carbomethoxyaniline 
• 4426-11-3 cyclobutanecarbonitrile 
• 496867-71-1 4-hydroxy-3-cyclobutylquinazoline 

Downstream Products

• 1448676-74-1 2-cyclobutyl-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline 

Relevant articles and documents

SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1

Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

Synthesis, resolution, and application of cyclobutyl- and adamantyl-quinazolinap ligands

An expedient, seven-step synthesis of two new members of the Quinazolinap ligand family, 2-cyclobutyl- and 2-(1-adamantyl)-Quinazolinaps, has been developed. The racemic ligands have been efficiently resolved by fractional crystallization of their diastereomeric palladacycle complexes. The enantioenriched ligands provide good levels of enantioselection (ee's up to 89%) in a prototypical PdII-catalyzed allylic alkylation reaction. 2-Cyclobutyl-Quinazolinap has been further functionalized at the 2-position via metalation with a superbase followed by reaction with a range of electrophiles. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.