109317-23-9

Basic information

• Product Name: 4-BROMO-2-METHYLPHENYLTHIOUREA
• Synonyms: 1-(4-BROMO-2-METHYLPHENYL)-2-THIOUREA;4-BROMO-2-METHYLPHENYLTHIOUREA;1-(4-bromo-2-methylphenyl)thiourea
• CAS NO: 109317-23-9
• Molecular Formula: C₈H₉BrN₂S
• Molecular Weight: 245.14
• EINECS: -0
• Mol File: 109317-23-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 194-196°C
• Boiling Point: 324.2°Cat760mmHg
• Flash Point: 149.9°C
• Appearance: /
• Density: 1.634g/cm³
• Vapor Pressure: 0.000249mmHg at 25°C
• Refractive Index: 1.719
• BRN: 3250571
• CAS DataBase Reference: 4-BROMO-2-METHYLPHENYLTHIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-METHYLPHENYLTHIOUREA(109317-23-9)
• EPA Substance Registry System: 4-BROMO-2-METHYLPHENYLTHIOUREA(109317-23-9)

Safety Data

• Hazard Codes: T
• Statements: 22-25
• Safety Statements: 22-36/37-45
• RIDADR: 2811
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 109317-23-9(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-methylphenylthiourea (BMTU) is a chemical compound with the molecular formula C8H8BrN3S. It is a white to off-white crystalline solid that is insoluble in water but soluble in organic solvents. BMTU has potential applications in pharmaceuticals, agrochemicals, and materials science. It is known to exhibit antifungal and antibacterial activities, making it a promising candidate for the development of antimicrobial agents. Additionally, BMTU has been studied for its potential use in the treatment of various diseases and disorders, including cancer and diabetes. However, further research is needed to fully understand the properties and potential applications of this chemical compound.

InChI:InChI=1/C8H9BrN2S/c1-5-4-6(9)2-3-7(5)11-8(10)12/h2-4H,1H3,(H3,10,11,12)

Upstream product

• 583-75-5 4-Bromo-2-methylaniline 
• 19241-38-4 4-bromo-2-methylphenyl isothiocyanate 

Downstream Products

• 109317-48-8 2-(4-Bromo-2-methyl-phenylamino)-5,5-dimethyl-5,6-dihydro-4H-benzothiazol-7-one; hydrobromide 
• 109317-28-4 (4-Bromo-2-methyl-phenyl)-(4,5,6,7-tetrahydro-benzothiazol-2-yl)-amine 
• 681126-45-4 6-bromo-4-methyl-1,3-benzothiazol-2-amine 

Relevant articles and documents

Design, synthesis, X-ray crystallographic analysis, and biological evaluation of thiazole derivatives as potent and selective inhibitors of human dihydroorotate dehydrogenase

Human dihydroorotate dehydrogenase (HsDHODH) is a flavin-dependent mitochondrial enzyme that has been certified as a potential therapeutic target for the treatment of rheumatoid arthritis and other autoimmune diseases. On the basis of lead compound 4, which was previously identified as potential HsDHODH inhibitor, a novel series of thiazole derivatives were designed and synthesized. The X-ray complex structures of the promising analogues 12 and 33 confirmed that these inhibitors bind at the putative ubiquinone binding tunnel and guided us to explore more potent inhibitors, such as compounds 44, 46, and 47 which showed double digit nanomolar activities of 26, 18, and 29 nM, respectively. Moreover, 44 presented considerable anti-inflammation effect in vivo and significantly alleviated foot swelling in a dose-dependent manner, which disclosed that thiazole-scaffold analogues can be developed into the drug candidates for the treatment of rheumatoid arthritis by suppressing the bioactivity of HsDHODH.