1089733-96-9Relevant articles and documents
A short enantioselective synthesis of (-)-bestatin via l-proline-catalyzed α-amination of an aldehyde
George, Shyla,Suryavanshi, Gurunath S.,Sudalai, Arumugam
scheme or table, p. 6791 - 6793 (2009/04/06)
A short and high yielding enantioselective synthesis of (-)-bestatin, a naturally occurring aminopeptidase inhibitor, is described via l-proline-catalyzed asymmetric α-amination of 3-phenylpropionaldehyde as the key reaction. The methodology also involves a Pd-catalyzed intramolecular cyclization of an allylic acetate giving a trans-oxazoline in a highly diastereoselective manner (dr > 14:1).