108831-66-9

Basic information

• Product Name: BUTTPARK 146\18-29
• Synonyms: BUTTPARK 146\18-29;6-METHYLTHIENO[2,3-D]PYRIMIDIN-4-OL;Thieno[2,3-d]pyrimidin-4(1H)-one, 6-methyl-;6-Methyl-3H,4H-thieno[2,3-d]pyriMidin-4-one;6-Methylthieno[2,3-d]pyrimidin-4(3H)-one;6-methyl-3H-thieno[3,2-e]pyrimidin-4-one;6-Methylthieno[2,3-d]Pyrimid-4-One;6-Methyl-1H-thieno[2,3-d]pyrimidin-4-one
• CAS NO: 108831-66-9
• Molecular Formula: C7H6N2OS
• Molecular Weight: 166.2
• Mol File: 108831-66-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 195-200℃ (ethanol )
• Boiling Point: 406.7°C at 760 mmHg
• Flash Point: 199.8°C
• Appearance: /
• Density: 1.53g/cm³
• Vapor Pressure: 7.97E-07mmHg at 25°C
• Refractive Index: 1.752
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 11.56±0.20(Predicted)
• CAS DataBase Reference: BUTTPARK 146\18-29(CAS DataBase Reference)
• NIST Chemistry Reference: BUTTPARK 146\18-29(108831-66-9)
• EPA Substance Registry System: BUTTPARK 146\18-29(108831-66-9)

Safety Data

• Statements: 20/21/22
• Safety Statements: 3/7-36/37
• Hazardous Substances Data: 108831-66-9(Hazardous Substances Data)

Usage

Chemical Properties

Yellow solid

InChI:InChI=1/C7H6N2OS/c1-4-2-5-6(10)8-3-9-7(5)11-4/h2-3H,1H3,(H,8,9,10)

Upstream product

• 19369-53-0 methyl 2-amino-5-methylthiophene-3-carboxylate 
• 77287-34-4 formamide 
• 4815-32-1 ethyl 2-amino-5-methylthiophene-3-carboxylate 

Downstream Products

• 106691-21-8 4-chloro-6-methylthieno<2,3-d>pyrimidine 
• 118376-67-3 2-(6-Methyl-4-oxo-4H-thieno[2,3-d]pyrimidin-3-yl)-propionic acid 
• 108099-55-4 6-Bromomethyl-4-chlorothieno<2,3-d>pyrimidine 
• 890014-20-7 [(6-methylthieno[2,3-d]pyrimidin-4-yl)thio]acetic acid 

Relevant articles and documents

THIENOPYRIMIDINONE NMDA RECEPTOR MODULATORS AND USES THEREOF

Disclosed herein, in part, are heteroaromatic compounds and methods of use in treating neuropsychiatric disorders, e.g., schizophrenia and major depressive disorder. Pharmaceutical compositions and methods of making heteroaromatic compounds are provided.

Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin- 4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2

A novel series of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids has been synthesized and tested in vitro towards human protein kinase CK2. It was revealed that the most active compounds inhibiting CK2 are 3-{[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]thio}propanoic acid and 3-{[5-(4-ethoxyphenyl)thieno[2,3-d]pyrimidin-4-yl]thio}propanoic acid (IC 50 values are 0.1 μM and 0.125 μM, respectively). Structure-activity relationships of 28 tested thienopyrimidine derivatives have been studied and binding mode of this chemical class has been predicted. Evaluation of the inhibitors on seven protein kinases revealed considerable selectivity towards CK2.

PSYCHOTROPIC HETEROBICYCLOALKYLPIPERAZINE DERIVATIVES

A series of psychotropic heterobicycloalkylpiperazine derivatives having the structure STR1 wherein V is a 3-or 4-membered unsaturated chain, containing all carbon atoms when 4-membered, or when a 3-membered chain, V contains an oxygen or sulfur atom as one of the members; R is H or C 1-4 alkyl; W is CH, N, CH 2, or a chemical bond; X is CH, N, SO 2, or CO, with the proviso that both W and X cannot simultaneously be N; and Z is a heteroaromatic ring system. These compounds are useful antipsychotic and/or anxiolytic agents.