108153-74-8

Basic information

• Product Name: Secretin (human)
• Synonyms: SECRETIN, HUMAN;HSDGTFTSELSRLREGARLQRLLQGLV-NH3;HSDGTFTSELSRLREGARLQRLLQGLV-NH2;HIS-SER-ASP-GLY-THR-PHE-THR-SER-GLU-LEU-SER-ARG-LEU-ARG-GLU-GLY-ALA-ARG-LEU-GLN-ARG-LEU-LEU-GLN-GLY-LEU-VAL-NH2;HIS-SER-ASP-GLY-THR-PHE-THR-SER-GLU-LEU-SER-ARG-LEU-ARG-GLU-GLY-ALA-ARG-LEU-GLN-ARG-LEU-LEU-GLN-GLY-LEU-VAL-NH2 HUMAN;H-HIS-SER-ASP-GLY-THR-PHE-THR-SER-GLU-LEU-SER-ARG-LEU-ARG-GLU-GLY-ALA-ARG-LEU-GLN-ARG-LEU-LEU-GLN-GLY-LEU-VAL-NH2;H-HIS-SER-ASP-GLY-THR-PHE-THR-SER-GLU-LEU-SER-ARG-LEU-ARG-GLU-GLY-ALA-ARG-LEU-GLN-ARG-LEU-LEU-GLN-GLY-LEU-VAL-NH3;SECRETINHCL
• CAS NO: 108153-74-8
• Molecular Formula: C130H220N44O40
• Molecular Weight: 3039.41
• EINECS: 241-105-3
• Product Categories: Peptide;Gastrointestinal Peptides;Hormones;Other Protein/Peptide Hormones;SecretinPeptides for Cell Biology;Secretins;VIP and PACAP receptor;EndocrinologyandHormones
• Mol File: 108153-74-8.mol
• Article Data: 0

Chemical Properties

• Appearance: /powder
• Density: 1.49±0.1 g/cm3(Predicted)
• Storage Temp.: −20°C
• CAS DataBase Reference: Secretin (human)(CAS DataBase Reference)
• NIST Chemistry Reference: Secretin (human)(108153-74-8)
• EPA Substance Registry System: Secretin (human)(108153-74-8)

Safety Data

• WGK Germany: 3
• RTECS: VS4030000
• Hazardous Substances Data: 108153-74-8(Hazardous Substances Data)

Usage

Description

Secretin (human) is a gastrointestinal hormone and a neuropeptide that is synthesized from a precursor protein. It shares sequence homology with other secretin family proteins such as glucagon and vasoactive intestinal peptide (VIP). Secretin plays a crucial role in the regulation of various physiological processes in the human body.

Uses

Used in Biomedical Research:
Secretin (human) is used as a research tool for studying the effects of this hormone on human endoderm stem cells (hEnSCs) and human induced pluripotent stem cells (iPSC)-derived biliary cells. It is particularly useful in the following applications:
1. Radioimmunoassay with Oxyntomodulin:
Secretin (human) is used as a test agent to evaluate its impact on the enlargement and swelling of human endoderm stem cells (hEnSCs) derived cysts. This application helps researchers understand the role of secretin in cellular growth and development.
2. Cyclic Adenosine Monophosphate (cAMP) Assays:
Secretin (human) is used to stimulate human induced pluripotent stem cells (iPSC)-derived biliary cells in cAMP assays. This application allows researchers to test the effect of secretin on cAMP production, which is an important second messenger in cellular signaling pathways.

Biochem/physiol Actions

Secretin regulates the secretion of gastric acid and pancreatic bicarbonates. It serves as an antidiuretic hormone in the neurohypophysial-renal axis and participates in osmoregulation. Secretin mediates its function through the G-protein coupled secretin receptors. It regulates the pH of the duodenal by modulating gastric acid secretion.